FGF21 induces autophagy-mediated cholesterol efflux to inhibit atherogenesis via RACK1 up-regulation

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成果类型：

期刊论文

作者：

Lin Xiaolong;Guo Dongmin;Liu, Mihua;Wang Zuo;Hu Huijun;...

通讯作者：

Zeng Zhaolin

作者机构：

[Lin Jun; Lin Wensheng; Hu Huijun; Hu XueMei; Tan Qiufen; Lin Xiaolong; Pan Yuping] Guangzhou Med Univ, Huizhou Third Peoples Hosp, Dept Pathol, Huizhou City, Peoples R China.

[Wang Zuo; Zeng Zhaolin; Guo Dongmin] Univ South China, Inst Cardiovasc Dis, Key Lab Arteriosclerol Hunan Prov, Hengyang City, Peoples R China.

[Liu, Mihua] Chongqing Med Univ, Affiliated Hosp 2, Dept Infect Dis, Ctr Lipid Res, Chongqing, Peoples R China.

[Liu, Mihua] Chongqing Med Univ, Affiliated Hosp 2, Key Lab Mol Biol Infect Dis, Minist Educ,Inst Viral Hepatitis, Chongqing, Peoples R China.

[Liu, Mihua] Gannan Med Univ, Dept Lab Med, Affiliated Hosp 1, Ganzhou City, Peoples R China.

通讯机构：

[Zeng Zhaolin] C

Chongqing Med Univ, Nanchuan Peoples Hosp, Dept Cardiol, Chongqing 408400, Peoples R China.

语种：

英文

关键词：

atherosclerosis;autophagy;fibroblast growth factor 21;RACK1

期刊：

Journal of Cellular and Molecular Medicine

ISSN：

1582-1838

年：

2020

卷：

期：

页码：

4992-5006

DOI：

10.1111/jcmm.15118

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81600342]; Medical Foundation of Hui Zhou [2019Y134]; Medical Research Foundation of Guangdong Province [A2018099]; Natural Science Foundation of Hunan ProvinceNatural Science Foundation of Hunan Province [2018JJ3459]; Education Department Foundation of Hunan Province [2016C1391]

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

Fibroblast growth factor 21 (FGF21) acts as an anti-atherosclerotic agent. However, the specific mechanisms governing this regulatory activity are unclear. Autophagy is a highly conserved cell stress response which regulates atherosclerosis (AS) by reducing lipid droplet degradation in foam cells. We sought to assess whether FGF21 could inhibit AS by regulating cholesterol metabolism in foam cells via autophagy and to elucidate the underlying molecular mechanisms. In this study, ApoE(-/-) mice were fed a high-fat diet (HFD) with or without FGF21 and FGF21 + 3-Methyladenine (3MA) for 12 weeks. ...

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FGF21 induces autophagy-mediated cholesterol efflux to inhibit atherogenesis via RACK1 up-regulation

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