Hippocampal ornithine decarboxylase/spermidine pathway mediates H2S-alleviated cognitive impairment in diabetic rats: Involving enhancment of hippocampal autophagic flux

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成果类型：

期刊论文

作者：

Kang, Xuan;Li, Cheng;Xie, Yan;He, Ling-Li;Xiao, Fan;...

通讯作者：

Tang, Xiao-Qing;Zhan, Ke-Bin

作者机构：

[Tang, Xiao-Qing; Kang, Xuan] Univ South China, Affiliated Hosp 1, Inst Neurol, 69 Chuanshan Rd, Hengyang 421001, Hunan, Peoples R China.

[Xiao, Fan; Tang, Xiao-Qing; Kang, Xuan; Tang, Yi-Yun] Univ South China, Hengyang Med Coll, Inst Neurosci, Hengyang 421001, Hunan, Peoples R China.

[Li, Cheng] Univ South China, Dept Emergency, Affiliated Nanhua Hosp, Hengyang 421001, Hunan, Peoples R China.

[Zhan, Ke-Bin; Li, Cheng; Xie, Yan; He, Ling-Li] Univ South China, Affiliated Hosp 2, Dept Neurol, 35 Jiefang Rd, Hengyang 421001, Hunan, Peoples R China.

[Li, Xiang] Univ South China, Affiliated Hosp 1, Dept Anesthesiol, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Tang, Xiao-Qing; Zhan, Ke-Bin] U

Univ South China, Affiliated Hosp 1, Inst Neurol, 69 Chuanshan Rd, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Affiliated Hosp 2, Dept Neurol, 35 Jiefang Rd, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

Autophagic flux;Cognitive impairment;Diabetes;Ornithine decarboxylase;spermidine;pathway;Hydrogen sulfide

期刊：

Journal of Advanced Research

ISSN：

2090-1232

年：

2021

卷：

页码：

31-40

DOI：

10.1016/j.jare.2020.06.007

基金类别：

This study is supported by National Natural Science Foundation of China ( 81671057 ) and Natural Science Foundation of Hunan province ( 2019JJ50546 , 2019JJ80101 , 2019JJ50556 ).

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Introduction: We have previously demonstrated the antagonistic role of hydrogen sulfide (H2S) in the cognitive dysfunction of streptozotocin (STZ)-induced diabetic rats. It has been confirmed that the impaired hippocampal autophagic flux has a key role in the pathogenesis of cognitive impairment and that ornithine decarboxylase (ODC)/spermidine (Spd) pathway plays an important role in the formation of memory by promoting autophagic flux. Objectives: To investigate the roles of hippocampal ODC/Spd pathway and autophagic flux in H2S-attenuated co...

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Hippocampal ornithine decarboxylase/spermidine pathway mediates H2S-alleviated cognitive impairment in diabetic rats: Involving enhancment of hippocampal autophagic flux

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