HPV E6/E7: insights into their regulatory role and mechanism in signaling pathways in HPV-associated tumor

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成果类型：

期刊论文

作者：

Peng, Qiu*;Wang, Lujuan;Zuo, Liang;Gao, Shuichao;Jiang, Xianjie;...

通讯作者：

Peng, Qiu;Tian, Hao;Zhou, Yujuan;Liao, QJ

作者机构：

[Gao, Shuichao; Han, Yaqian; Zhou, Yujuan; Jiang, Xianjie; Peng, Qiu; Liao, Qianjin; Peng, Mingjing; Tian, Hao; Tang, Yanyan; Zhou, YJ; Wu, Nayiyuan; Zuo, Liang; Lin, Jinguan] Cent South Univ, Hunan Canc Hosp, Hunan Key Lab Canc Metab, Changsha 410013, Hunan, Peoples R China.

[Gao, Shuichao; Han, Yaqian; Zhou, Yujuan; Jiang, Xianjie; Peng, Qiu; Liao, Qianjin; Peng, Mingjing; Tian, Hao; Tang, Yanyan; Zhou, YJ; Wu, Nayiyuan; Zuo, Liang; Lin, Jinguan] Cent South Univ, Affiliated Canc Hosp, Xiangya Sch Med, Changsha 410013, Hunan, Peoples R China.

[Wang, Lujuan] Cent South Univ, Second Xiangya Hosp, Hunan Key Lab Tumor Models & Individualized Med, Changsha 410011, Hunan, Peoples R China.

[Zhou, Yujuan; Liao, Qianjin; Zhou, YJ] Univ South China, Hengyang 421001, Hunan, Peoples R China.

[Zhou, Yujuan; Liao, Qianjin; Zhou, YJ] Publ Serv Platform Tumor Organoids Technol, 283 Tongzipo Rd, Changsha 410013, Hunan, Peoples R China.

通讯机构：

[Tian, H; Peng, Q; Liao, QJ ; Zhou, YJ] C

Cent South Univ, Hunan Canc Hosp, Hunan Key Lab Canc Metab, Changsha 410013, Hunan, Peoples R China.

Cent South Univ, Affiliated Canc Hosp, Xiangya Sch Med, Changsha 410013, Hunan, Peoples R China.

Univ South China, Hengyang 421001, Hunan, Peoples R China.

Publ Serv Platform Tumor Organoids Technol, 283 Tongzipo Rd, Changsha 410013, Hunan, Peoples R China.

语种：

英文

期刊：

Cancer Gene Therapy

ISSN：

0929-1903

年：

2024

卷：

期：

页码：

9-17

DOI：

10.1038/s41417-023-00682-3

基金类别：

This work was supported in part by grants from the following sources: the National Natural Science Foundation of China (82203233, 82202966, 81972636), the Natural Science Foundation of Hunan Province (2023JJ40413, 2023JJ40853, 2022JJ80078, 2021JJ70098, 2020JJ5336), the Research Project of Health Commission of Hunan Province (202302067467, 202203034978, 202109031837), Key Research and Development Program of Hunan Province (2022SK2051), Hunan Provincial Science and Technology Department (2020TP1018), the Changsha Science and Technology Board (kq2208337, kh2201054), Ascend Foundation of National cancer center (NCC201909B06), and by Hunan Cancer Hospital Climb Plan (ZX2020001-3, YF2020002), the science and technology innovation Program of Hunan Province (2023RC1073, 2023RC3199).

机构署名：

本校为通讯机构

摘要：

Human papillomavirus (HPV) is a class of envelope-free double-stranded DNA virus. HPV infection has been strongly associated with the development of many malignancies, such as cervical, anal and oral cancers. The viral oncoproteins E6 and E7 perform central roles on HPV-induced carcinogenic processes. During tumor development, it usually goes along with the activation of abnormal signaling pathways. E6 and E7 induces changes in cell cycle, proliferation, invasion, metastasis and other biological behaviors by affecting downstream tumor-related s...

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HPV E6/E7: insights into their regulatory role and mechanism in signaling pathways in HPV-associated tumor

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