期刊论文

Tu, Jian

英文

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

0193-1857

2019

316

5

G598-G607

10.1152/ajpgi.00061.2018

This work was supported by the National Natural Science Foundation of China (81541163); the Open Fund Based on Innovation Platform of Hunan Provincial Education Department (15K111); the High-level-talent research start-up fund of the University of South China in 2017XQD24; the Hunan Provincial Cooperative Innovation Center for Molecular Target New Drug Study (2016-429); and the Hunan key laboratory cultivation base of research and development of novel pharmaceutical preparations (no. 2016TP1029).

本校为第一且通讯机构

This study was conducted to observe the effect and possible mechanism of TO901317 in vivo and in vitro to provide a new basis for the targeted therapy of hepatocellular carcinoma (HCC). The expressions of liver X receptor (LXR)-alpha, glucose transporter (Glut)-1, proliferating cell nuclear antigen (PCNA), and matrix metalloproteinase (MMP)-9 were analyzed from HCC public database (NCBI PubMed database). The result showed that LXR alpha was downregulated, whereas Glut1. PCNA. and MMP9 were upregulated in human HCC compared with normal liver. Furthermore. LXR alpha mRNA was negatively correlate...