期刊论文

Li, Jie

英文

Vascular

1708-5381

2020

28

6

1708538120929504

10.1177/1708538120929504

National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81202535]; Hunan Provincial Department of Education [19K084, 19C1722]; Hunan Provincial Science and Technology Department [2018JJ6097]; Science and Technology Bureau of Chenzhou, Hunan Province [zdyf201925]; Research Center of Diagnosis and Treatment Technology for Lipid Metabolism Disorders of Chenzhou, Hunan Province [yfzx201907]

本校为第一且通讯机构

OBJECTIVES: Cardiovascular disease (CVD) remains the primary cause of morbidity and mortality worldwide. The abnormal proliferation of vascular smooth muscle cells (VSMCs) is a key event in the pathogenesis of CVD. The functional and phenotypic changes in vascular cells are mediated by complex signaling cascades that initiate and control genetic reprogramming. Many studies have demonstrated that signal transducer and activator of transcription 3 (STAT3) regulates a diverse array of functions relevant to atherosclerosis. METHODS: In this review, we summarize the studies on the STAT3-mediated pr...