期刊论文

Experimental and clinical study on negative pressure suction combined with nano-silver dressing for promoting healing of infected incision

中文

中国感染控制杂志

1671-9638

2017

16

10

931-935

10.3969/j.issn.1671-9638.2017.10.008

湖南省湘潭市科技计划项目（S2015S0013）；

本校为第一机构

目的 探讨自制负压装置联合纳米银敷料促进大鼠切口感染愈合的优势,并探究其临床疗效.方法 感染切口模型大鼠随机分为常规处理组、单纯负压吸引组、负压吸引联合银离子敷料组.治疗后评价各组大鼠切口愈合时间、愈合面积,对切口组织的炎症因子进行免疫组化及荧光定量分析.并将三组方法 应用于临床手术部位感染患者,比较分析各组患者切口的肉芽覆盖时间、肉芽痊愈时间和切口愈合时间.结果 大鼠肉芽组织免疫组织化学及IOD值、大鼠切口组织TNF-α、IL-2、IL-8的mRNA相对表达水平均低于常规处理组和单纯负压吸引组,差异有统计学差异(P

Objective To evaluate the advantage of homemade negative pressure device combined with nano-silver dressing for promoting the healing of infected incision in rats, and explore its clinical curative effect. Methods In- fected incision model rats were randomly divided into conventional treatment group, and simple pressure suction group, pressure suction combined with silver ion dressing group. The healing time and healing area of rats in each group after treatment were evaluated, immunohistochemical and fluorescent quantitative analysis of inflam...