O-GlcNAc modification of GSDMD attenuates LPS-induced endothelial cells pyroptosis

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成果类型：

期刊论文

作者：

Yu, Fan;Zhang, Zhen;Leng, Yiping;Chen, Alex F.

通讯作者：

Chen, AF

作者机构：

[Chen, Alex F.; Zhang, Zhen; Yu, Fan] Cent South Univ, Dept Cardiol, Xiangya Hosp 3, Changsha, Peoples R China.

[Yu, Fan] Zhejiang Univ, Res Ctr Life Sci & Human Hlth, Binjiang Inst, Hangzhou, Zhejiang, Peoples R China.

[Leng, Yiping] Univ South China, Affiliated Changsha Cent Hosp, Res Ctr PhaseClin Trials 1, Hengyang Med Sch, Changsha, Hunan, Peoples R China.

[Chen, Alex F.] Shanghai Jiao Tong Univ, Inst Cardiovasc Dev & Regenerat Med, Dept Cardiol, Sch Med,Xinhua Hosp, 1665 Kongjiang Rd, Shanghai 200092, Peoples R China.

通讯机构：

[Chen, AF ] C

Cent South Univ, Dept Cardiol, Xiangya Hosp 3, Changsha, Peoples R China.

Shanghai Jiao Tong Univ, Inst Cardiovasc Dev & Regenerat Med, Dept Cardiol, Sch Med,Xinhua Hosp, 1665 Kongjiang Rd, Shanghai 200092, Peoples R China.

语种：

英文

关键词：

GSDMD;O-GlcNAc;Sepsis;Endothelial;Pyroptosis

期刊：

Inflammation Research

ISSN：

1023-3830

年：

2024

卷：

期：

页码：

5-17

DOI：

10.1007/s00011-023-01812-1

基金类别：

This work was supported in part by grants from the Ministry of Science and Technology of China (2021YFA0804803), the Major Project of Natural Science Foundation of Hunan Province (Open Competition) (2021JC0002) and the National Science Foundation of China (81930012, 82241027).

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摘要：

OBJECTIVE: Increased O-linked β-N-acetylglucosamine (O-GlcNAc) stimulation has been reported to protect against sepsis associated mortality and cardiovascular derangement. Previous studies, including our own research, have indicated that gasdermin-D(GSDMD)-mediated endothelial cells pyroptosis contributes to sepsis-associated endothelial injury. This study explored the functions and mechanisms of O-GlcNAc modification on lipopolysaccharide (LPS)-induced pyroptosis and its effects on the function of GSDMD. METHODS: A LPS-induced septic mouse mo...

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O-GlcNAc modification of GSDMD attenuates LPS-induced endothelial cells pyroptosis

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