MC-LR induced apoptosis in human embryonic kidney (HEK293) cells through activation of TNF-R1/RIPK1 pathway

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Wang, Yaqi;Yang, Yue;Yuan, Mei;Yang, Fei;Zeng, Wen;...

通讯作者：

Liu, Jun;Zhan, CH

作者机构：

[Liu, Jun; Zhan, Chunhua; Yang, Yue; Yang, Fei; Wang, Yaqi] Univ South China, Sch Basic Med Sci, Sch Publ Hlth, Hunan Key Lab Typ Environm Pollut & Hlth Hazards,H, Hengyang 421001, Hunan, Peoples R China.

[Zeng, Wen; Zhan, Chunhua] Cent Hosp Shaoyang, Dept Publ Hlth, Shaoyang, Peoples R China.

[Yuan, Mei] Univ South China, Affiliated Hosp 2, Hengyang Med Sch, Dept Neurol, Hengyang, Hunan, Peoples R China.

[Zhan, Chunhua] Univ South China, Key Lab Rare Pediat Dis, Minist Educ, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Liu, J; Zhan, CH ] U

Univ South China, Sch Basic Med Sci, Sch Publ Hlth, Hunan Key Lab Typ Environm Pollut & Hlth Hazards,H, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Key Lab Rare Pediat Dis, Minist Educ, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

MC-LR;Apoptosis;TNF-R1;RIPK1;HEK293

期刊：

JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

ISSN：

1528-7394

年：

2025

卷：

期：

页码：

339-348

DOI：

10.1080/15287394.2024.2439532

基金类别：

ClinicaResearch Center For Prevention and Treatment of Cognitive Impairment In Hunan Province [2023SK4050]; Hunan Provincial Natural Science Youth Fund [2024JJ6392]; Health Research Project of Hunan Provincial Health Commission [202203064882]; Hunan Key Laboratory of Typical Environmental Pollution and Health Hazards, School of Public Health, Hengyang Medical School, University of South China [2019TP1027]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

公共卫生学院

摘要：

In recent years, the outbreak of cyanobacterial blooms has become increasingly frequent. Microcystin-LR (MC-LR), a metabolite of cyanobacteria, poses a significant threat to the ecosystem and human health. Several studies have demonstrated that MC-LR might induce renal cell apoptosis, as a consequence of tissue damage. However, the molecular mechanisms underlying MC-LR-initiated renal injury remain to be determined. This investigation aimed to determine the role of apoptosis in MC-LR-induced kidney damage and its potential underlying mechanisms...

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MC-LR induced apoptosis in human embryonic kidney (HEK293) cells through activation of TNF-R1/RIPK1 pathway

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