Hypoxia promotes the invasion and metastasis of laryngeal cancer cells via EMT

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Zuo, Jianhong;Wen, Juan;Lei, Mingsheng;Wen, Meiling;Li, Sai;...

通讯作者：

Luo, Zhaoyang;Wen, Gebo

作者机构：

[Wen, Gebo; Zuo, Jianhong; Luo, Zhaoyang; Wen, GB; Lv, Xiu; Li, Sai; Wen, Juan] Univ South China, Sch Med, Hengyang 421001, Hunan, Peoples R China.

[Zuo, Jianhong; Lv, Xiu; Wen, Meiling; Li, Sai] Univ South China, Nanhua Hosp, Hengyang 421000, Hunan, Peoples R China.

[Lei, Mingsheng] Zhangjiajie City Hosp, Dept Resp & Crit Care Med, Zhangjiajie 427000, Hunan, Peoples R China.

通讯机构：

[Luo, ZY; Wen, GB] U

Univ South China, Sch Med, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

E-cadherin;Epithelial-mesenchymal transition;Glucose transporter-1;Laryngeal carcinoma;Vimentin

期刊：

Medical Oncology

ISSN：

1357-0560

年：

2016

卷：

期：

页码：

1-9

DOI：

10.1007/s12032-015-0716-6

基金类别：

National Nature Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81272960]; Key Research Program from Science and Technology Department of Hunan Province, China [2013WK2010]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

The purpose of this study is to explore the role of hypoxia on the invasion and metastasis of laryngeal carcinoma. The invasion and migration ability of laryngeal cancer SCC10A cell was detected by transwell assay. Western blot was applied to analyze the expression of EMT-related proteins. Fifty-seven samples from postoperative patients with laryngeal cancer were collected to study. Immunohistochemistry was used to examine the expression of GLUT-1 and EMT-related proteins (Vim, E-cad, N-cad) in normal laryngeal squamous epithelial tissue, laryn...

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Hypoxia promotes the invasion and metastasis of laryngeal cancer cells via EMT

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