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Hypoxia promotes the invasion and metastasis of laryngeal cancer cells via EMT

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成果类型:
期刊论文
作者:
Zuo, Jianhong;Wen, Juan;Lei, Mingsheng;Wen, Meiling;Li, Sai;...
通讯作者:
Luo, Zhaoyang;Wen, Gebo
作者机构:
[Wen, Gebo; Zuo, Jianhong; Luo, Zhaoyang; Wen, GB; Lv, Xiu; Li, Sai; Wen, Juan] Univ South China, Sch Med, Hengyang 421001, Hunan, Peoples R China.
[Zuo, Jianhong; Lv, Xiu; Wen, Meiling; Li, Sai] Univ South China, Nanhua Hosp, Hengyang 421000, Hunan, Peoples R China.
[Lei, Mingsheng] Zhangjiajie City Hosp, Dept Resp & Crit Care Med, Zhangjiajie 427000, Hunan, Peoples R China.
通讯机构:
[Luo, ZY; Wen, GB] U
Univ South China, Sch Med, Hengyang 421001, Hunan, Peoples R China.
语种:
英文
关键词:
beta actin;glucose transporter 1;hypoxia inducible factor 1alpha;nerve cell adhesion molecule;uvomorulin;vimentin;cadherin;CDH2 protein, human;glucose transporter 1;leukocyte antigen;SLC2A1 protein, human;vimentin;Article;cancer patient;cancer prognosis;cancer staging;cell migration;controlled study;epithelial mesenchymal transition;human;human cell;human tissue;hypoxia;immunohistochemistry;larynx cancer;larynx carcinoma;larynx squamous cell carcinoma;lymph node metastasis;priority journal;protein expression;survival rate;survival time;tumor invasion;Western blotting;aged;cell hypoxia;cell motion;larynx tumor;lymph node metastasis;metabolism;middle aged;mortality;pathology;physiology;squamous cell carcinoma;tumor cell culture;Aged;Antigens, CD;Cadherins;Cell Hypoxia;Cell Movement;Epithelial-Mesenchymal Transition;Glucose Transporter Type 1;Humans;Laryngeal Neoplasms;Lymphatic Metastasis;Middle Aged;Neoplasms, Squamous Cell;Survival Rate;Tumor Cells, Cultured;Vimentin
期刊:
Medical Oncology
ISSN:
1357-0560
年:
2016
卷:
33
期:
2
页码:
1-9
基金类别:
This work was supported by National Nature Science Foundation of China (81272960), Key Research Program from Science and Technology Department of Hunan Province, China (2013WK2010).
机构署名:
本校为第一且通讯机构
院系归属:
医学院
摘要:
The purpose of this study is to explore the role of hypoxia on the invasion and metastasis of laryngeal carcinoma. The invasion and migration ability of laryngeal cancer SCC10A cell was detected by transwell assay. Western blot was applied to analyze the expression of EMT-related proteins. Fifty-seven samples from postoperative patients with laryngeal cancer were collected to study. Immunohistochemistry was used to examine the expression of GLUT-1 and EMT-related proteins (Vim, E-cad, N-cad) in normal laryngeal squamous epithelial tissue, laryn...

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