The sirtuin 6 prevents angiotensin II-mediated myocardial fibrosis and injury by targeting AMPK-ACE2 signaling

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成果类型：

期刊论文

作者：

Zhang, Zhen-Zhou;Cheng, Yu-Wen;Jin, Hai-Yan;Chang, Qing;Shang, Qian-Hui;...

通讯作者：

Zhong, Jiu-Chang

作者机构：

[Zhong, Jiu-Chang; Song, Bei; Cheng, Yu-Wen; Jin, Hai-Yan; Xu, Ying-Le; Xu, Ran; Zhang, Zhen-Zhou; Chang, Qing] Shanghai Jiao Tong Univ, Shanghai Inst Hypertens, Shanghai Key Lab Hypertens, State Key Lab Med Genom,Ruijin Hosp,Sch Med, Shanghai 200025, Peoples R China.

[Zhong, Jiu-Chang; Zhang, Zhen-Zhou] Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Shanghai 200025, Peoples R China.

[Jin, Hai-Yan] Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Dept Mental Hlth, Shanghai 200025, Peoples R China.

[Shang, Qian-Hui] Zunyi Med Coll, Affiliated Hosp, Dept Cardiol, Zunyi 563003, Peoples R China.

[Shang, Qian-Hui] Zunyi Med Coll, Affiliated Hosp, Inst Clin Med Res, Zunyi 563003, Peoples R China.

通讯机构：

[Zhong, Jiu-Chang] S

[Zhong, Jiu-Chang] C

Shanghai Jiao Tong Univ, Shanghai Inst Hypertens, Shanghai Key Lab Hypertens, State Key Lab Med Genom,Ruijin Hosp,Sch Med, Shanghai 200025, Peoples R China.

Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Shanghai 200025, Peoples R China.

语种：

英文

关键词：

SIRT6;angiotensin-converting enzyme 2;connective tissue growth factor;fibrosis;myocardial injury

期刊：

Oncotarget

ISSN：

1949-2553

年：

2017

卷：

期：

页码：

72302-72314

DOI：

10.18632/oncotarget.20305

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81370362, 81770253]; National Basic Research Program of China (973 Program)National Basic Research Program of China [2014CB542300]; National Major Research Plan Training Program [91339108]; Scientific Research Project of Health Bureau of Shanghai [201440368]; Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant [20152509]

机构署名：

本校为其他机构

院系归属：

药学与生物科学学院

摘要：

Sirtuin 6 (SIRT6) is an important modulator of cardiovascular functions in health and diseases. However, the exact role of SIRT6 in heart disease is poorly defined. We hypothesized that SIRT6 is a negative regulator of angiotensin II (Ang II)-mediated myocardial remodeling, fibrosis and injury. The male Sprague-Dawley rats were randomized to Ang II (200 ng/kg/min) infusion with an osmotic minipump and pretreated with recombinant plasmids adeno-associated viral vector (AAV)-SIRT6 (pAAV-SIRT6) or pAAV-GFP for 4 weeks. Ang II triggered downregulated levels of SIRT6 and angiotensin-converting enzy...

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The sirtuin 6 prevents angiotensin II-mediated myocardial fibrosis and injury by targeting AMPK-ACE2 signaling

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