A novel long non-coding RNA-KAT7 is low expressed in colorectal cancer and acts as a tumor suppressor

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成果类型：

期刊论文

作者：

Wang, Qingmei;He, Rongzhang;Tan, Tan;Li, Jia;Hu, Zheng;...

通讯作者：

Luo, Dixian

作者机构：

[Li, Jia; Hu, Zheng; Luo, Wenna; He, Rongzhang; Luo, Weihao; Duan, Lili; Luo, Dixian; Wang, Qingmei; Tan, Tan] Univ South China, Peoples Hosp Chenzhou 1, Natl & Local Joint Engn Lab High High Throughput, Translat Med Inst, Chenzhou 423000, Peoples R China.

[Luo, Dixian; Wang, Qingmei; Tan, Tan] Univ South China, Peoples Hosp Chenzhou 1, Ctr Clin Pathol, Chenzhou 423000, Peoples R China.

[He, Rongzhang] Cent S Univ, Xiangya Hosp, Dept Clin Pharmacol, Changsha 410078, Hunan, Peoples R China.

通讯机构：

[Luo, Dixian] U

Univ South China, Peoples Hosp Chenzhou 1, Natl & Local Joint Engn Lab High High Throughput, Translat Med Inst, Chenzhou 423000, Peoples R China.

语种：

英文

关键词：

lncRNA-KAT7;Colorectal cancer;Proliferation;Invasion;Migration;Tumor suppressor

期刊：

Cancer Cell International

ISSN：

1475-2867

年：

2019

卷：

期：

页码：

1-13

DOI：

10.1186/s12935-019-0760-y

基金类别：

Hunan Province Science Fund for Distinguished Young Schol#&#&#2018JJ1021 Key R&D Program of Hunan Province#&#&#2017SK2172 Natural Science Foundation ofHunan Province#&#&#2017JJ2003#&#&#2017JJ2004 Hunan Province Technological Innovation Guiding Plan, Clinical Medical Technology Innovation Guidance Project#&#&#2017SK51101 Hunan Provincial Science and Technology Department#&#&#B2017182#&#&#B20180378#&#&#B20180266 Science and Technique Foundation of Chenzhou#&#&#jsyf2017021#&#&#jsyf2017023

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Background: The abnormal expression of many long non-coding RNAs (lncRNAs) has been reported in the progression of various tumors. However, the potential biological roles and regulatory mechanisms of long non-coding RNAs in the development of colorectal cancer (CRC) have not yet been fully elucidated. Therefore, it is crucial to identify that lncRNAs can be used for the clinical prevention and treatment of CRC. Methods: In our previous work, we identificated a novel lncRNA, lncRNA-KAT7, and found that the expression of lncRNA-KAT7 in CRC tissues was significantly lower than that in matched nor...

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A novel long non-coding RNA-KAT7 is low expressed in colorectal cancer and acts as a tumor suppressor

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