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Protein arginine N-methyltransferase 2 reverses tamoxifen resistance in breast cancer cells through suppression of ER-α36

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成果类型:
期刊论文
作者:
Shen, Yingying;Zhong, Jing;Liu, Jianghua;Liu, Kehuang;Zhao, Jun;...
通讯作者:
Zu, Xuyu;Cao, Renxian
作者机构:
[Wen, Gebo; Zu, Xuyu; Cao, RX; Zhong, Jing; Cao, Renxian; Liu, Jianghua; Ding, Wenjun; Shen, Yingying] Univ South China, Affiliated Hosp 1, Inst Clin Med, 69 Chuanshan Rd, Hengyang 421001, Hunan, Peoples R China.
[Liu, Kehuang; Chen, Yajun; Cao, Renxian; Zeng, Ting; Zhao, Jun; Liu, Jianghua; Li, Zhimei; Xu, Ting] Univ South China, Affiliated Hosp 1, Dept Metab & Endocrinol, Hengyang 421001, Hunan, Peoples R China.
通讯机构:
[Zu, XY; Cao, RX] U
Univ South China, Affiliated Hosp 1, Inst Clin Med, 69 Chuanshan Rd, Hengyang 421001, Hunan, Peoples R China.
语种:
英文
关键词:
estrogen receptor alpha;estrogen receptor alpha36;methyltransferase;mitogen activated protein kinase;phosphatidylinositol 3 kinase;PRMT2 protein;protein kinase B;tamoxifen;unclassified drug;estrogen receptor alpha;estrogen receptor alpha, human;phosphatidylinositol 3 kinase;PRMT2 protein, human;protein arginine methyltransferase;protein kinase B;signal peptide;tamoxifen;Article;breast cancer cell line;cancer growth;cancer hormone therapy;cancer resistance;controlled study;human;human cell;human tissue;MAPK signaling;MCF-7 cell line;MDA-MB-231 cell line;priority journal;protein function;protein protein interaction;breast tumor;down regulation;drug effect;drug resistance;female;gene expression regulation;metabolism;tissue microarray;tumor cell line;Breast Neoplasms;Cell Line, Tumor;Down-Regulation;Drug Resistance, Neoplasm;Estrogen Receptor alpha;Female;Gene Expression Regulation, Neoplastic;Humans;Intracellular Signaling Peptides and Proteins;MAP Kinase Signaling System;MCF-7 Cells;Phosphatidylinositol 3-Kinases;Protein-Arginine N-Methyltransferases;Proto-Oncogene Proteins c-akt;Tamoxifen;Tissue Array Analysis
期刊:
ONCOLOGY REPORTS
ISSN:
1021-335X
年:
2018
卷:
39
期:
6
页码:
2604-2612
基金类别:
The present study was supported by the National Natural Science Foundation of China (grant nos. 81502276, 81372824, 81472608 and 81773294), the Major Projects of Science and Technology of Health and Family Planning Commission of Hunan Province (grant no. A2017013), the Natural Science Foundation of Hunan Province (grant no. 2016JJ4077), the Key Project of the Education Department of Hunan Province (grant no. 16A189) and the Young Talents Program of University of South China.
机构署名:
本校为第一且通讯机构
院系归属:
医学院
摘要:
Breast cancer is one of the most common malignancies in females, and 17β-estradiol (E2)/estrogen receptor α (ERα) signaling plays an important role in the initiation and progression of breast cancer. The role of the ER-α subtype and its co-regulator in the initiation of breast cancer and the occurrence of tamoxifen resistance remains to be further elucidated. In our previous studies, protein arginine N-methyltransferase 2 (PRMT2), a co-regulator of estrogen receptor-α (ER-α), was confirmed to interact with ER-α66 and has the ability to i...

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