Protein arginine N-methyltransferase 2 reverses tamoxifen resistance in breast cancer cells through suppression of ER-alpha 36

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成果类型：

期刊论文

作者：

Shen, Yingying;Zhong, Jing;Liu, Jianghua;Liu, Kehuang;Zhao, Jun;...

通讯作者：

Zu, Xuyu;Cao, Renxian

作者机构：

[Wen, Gebo; Zu, Xuyu; Cao, RX; Zhong, Jing; Cao, Renxian; Liu, Jianghua; Ding, Wenjun; Shen, Yingying] Univ South China, Affiliated Hosp 1, Inst Clin Med, 69 Chuanshan Rd, Hengyang 421001, Hunan, Peoples R China.

[Liu, Kehuang; Chen, Yajun; Cao, Renxian; Zeng, Ting; Zhao, Jun; Liu, Jianghua; Li, Zhimei; Xu, Ting] Univ South China, Affiliated Hosp 1, Dept Metab & Endocrinol, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Zu, XY; Cao, RX] U

Univ South China, Affiliated Hosp 1, Inst Clin Med, 69 Chuanshan Rd, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

protein arginine N-methyltransferase 2;PRMT2;ER-alpha 36;breast cancer;tamoxifen;resistance

期刊：

ONCOLOGY REPORTS

ISSN：

1021-335X

年：

2018

卷：

期：

页码：

2604-2612

DOI：

10.3892/or.2018.6350

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81502276, 81372824, 81472608, 81773294]; Major Projects of Science and Technology of Health and Family Planning Commission of Hunan Province [A2017013]; Natural Science Foundation of Hunan ProvinceNatural Science Foundation of Hunan Province [2016JJ4077]; Key Project of the Education Department of Hunan Province [16A189]; Young Talents Program of University of South China

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Breast cancer is one of the most common malignancies in females, and 17β-estradiol (E2)/estrogen receptor α (ERα) signaling plays an important role in the initiation and progression of breast cancer. The role of the ER-α subtype and its co-regulator in the initiation of breast cancer and the occurrence of tamoxifen resistance remains to be further elucidated. In our previous studies, protein arginine N-methyltransferase 2 (PRMT2), a co-regulator of estrogen receptor-α (ER-α), was confirmed to interact with ER-α66 and has the ability to i...

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Protein arginine N-methyltransferase 2 reverses tamoxifen resistance in breast cancer cells through suppression of ER-alpha 36

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