Natural product evodiamine-inspired medicinal chemistry: Anticancer activity, structural optimization and structure-activity relationship

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成果类型：

期刊论文

作者：

Wang, Zhen*;Xiong, Yongxia;Peng, Ying;Zhang, Xi;Li, Shuang;...

通讯作者：

Wang, Zhen;Zhuo, Linsheng;Jiang, WF

作者机构：

[Peng, Yan; Wang, Zhen; Peng, Ying; Peng, Xue; Li, Shuang; Xiong, Yongxia; Jiang, Weifan; Zhuo, Linsheng; Zhuo, LS] Univ South China, Sch Pharmaceut Sci, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.

[Zhuo, Linsheng; Jiang, Weifan] Univ South China, Hengyang Med Sch, Postdoctoral Stn Basic Med, Hengyang 421001, Hunan, Peoples R China.

[Peng, Ying; Wang, Zhen; Zhang, Xi] Univ South China, Sch Basic Med, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.

[Jiang, Weifan; Zhuo, Linsheng; Zhuo, LS] Univ South China, Sch Pharmaceut Sci, Hengyang Med Sch, Postdoctoral Stn Basic Med, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Wang, Z; Jiang, WF ; Zhuo, LS] U

Univ South China, Sch Pharmaceut Sci, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Sch Pharmaceut Sci, Hengyang Med Sch, Postdoctoral Stn Basic Med, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

Anticancer activity;Evodiamine derivatives;Structural optimization;Structure-activity relationship

期刊：

European Journal of Medicinal Chemistry

ISSN：

0223-5234

年：

2023

卷：

247

页码：

115031

DOI：

10.1016/j.ejmech.2022.115031

基金类别：

This review was supported by Gansu Province Science Foundation for Distinguished Young Scholars ( 20JR5RA304 ), National Natural Science Foundation of China ( 22107034 ), and Hunan Provincial Natural Science Foundation of China ( 2022JJ40356 ).

机构署名：

本校为第一且通讯机构

摘要：

It is a well-known phenomenon that natural products can serve as powerful drug leads to generate new molecular entities with novel therapeutic utility. Evodiamine (Evo), a major alkaloid component in traditional Chinese medicine Evodiae Fructus, is considered a desirable lead scaffold as its multifunctional pharmacological properties. Although natural Evo has suboptimal biological activity, poor pharmacokinetics, low water solubility, and chemical instability, medicinal chemists have succeeded in producing synthetic analogs that overshadow the deficiency of Evo in terms of further clinical app...

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Natural product evodiamine-inspired medicinal chemistry: Anticancer activity, structural optimization and structure-activity relationship

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