Human forebrain organoid-based multi-omics analyses of PCCB as a schizophrenia associated gene linked to GABAergic pathways

首页 > 成果 > 详情

认领

导出

Link by DOI

反馈

作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Zhang, Wendiao;Zhang, Ming;Xu, Zhenhong;Yan, Hongye;Wang, Huimin;...

通讯作者：

Liu, Chunyu;Chen, C;Meng, QT;Liu, CY

作者机构：

[Zhang, Wendiao; Liu, Chunyu; Chen, C; Chen, Chao; Zhang, Ming] Cent South Univ, Xiangya Hosp 2, Ctr Med Genet, Changsha 410008, Hunan, Peoples R China.

[Zhang, Wendiao; Liu, Chunyu; Chen, C; Chen, Chao; Zhang, Ming] Cent South Univ, Xiangya Hosp 2, Sch Life Sci, Hunan Key Lab Med Genet, Changsha 410008, Hunan, Peoples R China.

[Zhang, Wendiao; Liu, Chunyu; Chen, C; Chen, Chao; Zhang, Ming] Cent South Univ, Xiangya Hosp 2, Dept Psychiat, Changsha 410008, Hunan, Peoples R China.

[Meng, Qingtuan; Zhang, Wendiao; Yan, Hongye; Tang, Beisha; Xu, Zhenhong; Jiang, Jiamei; Wan, Juan; Wang, Huimin] Univ South China, Affiliated Hosp 1, Multiom Res Ctr Brain Disorders, Hengyang Med Sch, Hengyang 421000, Hunan, Peoples R China.

[Meng, Qingtuan; Zhang, Wendiao; Yan, Hongye; Tang, Beisha; Xu, Zhenhong; Jiang, Jiamei; Wan, Juan; Wang, Huimin] Univ South China, Affiliated Hosp 1, Clin Res Ctr Immune Related Encephalopathy Hunan P, Hengyang Med Sch, Hengyang 421000, Hunan, Peoples R China.

通讯机构：

[Meng, QT ] U

[Liu, CY ] S

[Liu, CY; Chen, C ] C

Cent South Univ, Xiangya Hosp 2, Ctr Med Genet, Changsha 410008, Hunan, Peoples R China.

Cent South Univ, Xiangya Hosp 2, Sch Life Sci, Hunan Key Lab Med Genet, Changsha 410008, Hunan, Peoples R China.

语种：

英文

期刊：

Nature Communications

ISSN：

2041-1723

年：

2023

卷：

期：

页码：

5176

DOI：

10.1038/s41467-023-40861-2

基金类别：

This work was supported by grants from the National Natural Science Foundation of China (Nos. 82171504, 82022024, 31970572, and 81901359), the Natural Science Foundation of Hunan Province (No. 2022JJ20035), the Science and Technology Innovation Program of [82022024, 31970572, 81901359, 2022JJ20035]; National Natural Science Foundation of China [2022RC1214]; Natural Science Foundation of Hunan Province [2020CX003]; Science and Technology Innovation Program of Hunan Province [1U01MH116489]; Innovation-Driven Project of Central South University [U01MH103392, U01MH103365, U01MH103346, U01MH103340, U01MH103339, R21MH109956, R21MH105881, R21MH105853, R21MH103877, R21MH102791, R01MH111721, R01MH110928, R01MH110927, R01MH110926, R01MH110921, R01MH110920, R01MH110905, R01MH109715, R01MH109677, R01MH105898, R01MH094714, P50MH106934]; National Institute of Health; [82171504]

机构署名：

本校为通讯机构

院系归属：

医学院

摘要：

Identifying genes whose expression is associated with schizophrenia (SCZ) risk by transcriptome-wide association studies (TWAS) facilitates downstream experimental studies. Here, we integrated multiple published datasets of TWAS, gene coexpression, and differential gene expression analysis to prioritize SCZ candidate genes for functional study. Convergent evidence prioritized Propionyl-CoA Carboxylase Subunit Beta (PCCB), a nuclear-encoded mitochondrial gene, as an SCZ risk gene. However, the PCCB’s contribution to SCZ risk has not been invest...

反馈

产权有误：本人成果被他人认领

数据有误：数据基本信息有误

归属有误：成果的院系归属、机构署名归属有误

其他原因：

验证码：

看不清楚，换一个

确定

取消

成果认领

标题：

用户	作者	通讯作者	--
	请选择	请选择	--

确定

取消

Human forebrain organoid-based multi-omics analyses of PCCB as a schizophrenia associated gene linked to GABAergic pathways

反馈

成果认领

提示

该栏目需要登录且有访问权限才可以访问