Human forebrain organoids reveal connections between valproic acid exposure and autism risk

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成果类型：

期刊论文

作者：

Meng, Qingtuan;Zhang, Wendiao;Wang, Xuan;Jiao, Chuan;Xu, Sheng;...

通讯作者：

Tang, Beisha;Chen, Chao

作者机构：

[Tang, Beisha; Meng, Qingtuan] Univ South China, Multi Om Res Ctr Brain Disorders, Hengyang Med Sch, Affiliated Hosp 1, Hengyang 421001, Hunan, Peoples R China.

[Zhang, Wendiao; Xu, Sheng; Chen, Chao; Wang, Xuan] Cent South Univ, Xiangya Hosp 2, Ctr Med Genet, Changsha 410008, Hunan, Peoples R China.

[Zhang, Wendiao; Xu, Sheng; Chen, Chao; Wang, Xuan] Cent South Univ, Xiangya Hosp 2, Hunan Key Lab Med Genet, Sch Life Sci, Changsha 410008, Hunan, Peoples R China.

[Zhang, Wendiao; Xu, Sheng; Chen, Chao; Wang, Xuan] Cent South Univ, Xiangya Hosp 2, Dept Psychiat, Changsha 410008, Hunan, Peoples R China.

[Jiao, Chuan; Liu, Chunyu] SUNY Upstate Med Univ, Dept Psychiat, Syracuse, NY 13210 USA.

通讯机构：

[Chen, Chao] C

[Tang, Beisha] T

The First Affiliated Hospital, Multi-Omics Research Center for Brain Disorders, Hengyang Medical School, University of South China, 421001, Hengyang, Hunan, China.

Center for Medical Genetics & Hunan Key Laboratory of Medical Genetics, School of Life Sciences, and Department of Psychiatry, The Second Xiangya Hospital, Central South University, 410008, Changsha, Hunan, China.

Hunan Key Laboratory of Animal Models for Human Diseases, Central South University, 410008, Changsha, Hunan, China.

语种：

英文

期刊：

TRANSLATIONAL PSYCHIATRY

ISSN：

2158-3188

年：

2022

卷：

期：

页码：

130

DOI：

10.1038/s41398-022-01898-x

基金类别：

National Natural Science Foundation of China (NSFC) [82171504, 82022024, 31970572, 81901359]; National Key R&D Project of China [2016YFC1306000, 2017YFC0908701]; Guangxi Natural Science Foundation [2020AC20026]; Innovation-Driven Project of Central South University [2020CX003]; NIH [1U01MH116489]

机构署名：

本校为第一机构

摘要：

Valproic acid (VPA) exposure as an environmental factor that confers risk of autism spectrum disorder (ASD), its functional mechanisms in the human brain remain unclear since relevant studies are currently restricted to two-dimensional cell cultures and animal models. To identify mechanisms by which VPA contribute to ASD risk in human, here we used human forebrain organoids (hFOs), in vitro derived three-dimensional cell cultures that recapitulate key human brain developmental features. We identified that VPA exposure in hFOs affected the expression of genes enriched in neural development, syn...

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Human forebrain organoids reveal connections between valproic acid exposure and autism risk

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