期刊论文

中文

中国循环杂志

1000-3614

2022

37

5

526-532

本校为第一机构

目的:探究薯蓣皂苷元对心肌缺血再灌注损伤(MIRI)大鼠细胞凋亡的影响,并初步分析其对NOD样受体蛋白3(NLRP3)/半胱氨酸天冬氨酸特异性蛋白酶1(Caspase-1)信号通路的作用。方法:采用左冠状动脉前降支结扎法建立MIRI大鼠模型,将造模成功的72只大鼠,按照随机数字表法分成MIRI组、薯蓣皂苷元低剂量组(50 mg/kg)、薯蓣皂苷元中剂量组(75 mg/kg)和薯蓣皂苷元高剂量组(100 mg/kg),每组18只;另取18只大鼠为假手术组。造模完成后,给予相应药物灌胃,每日1次。末次给药后,记录每组大鼠在不同时间段的心脏血液动力学参数;三苯基四氮唑(TTC)法检测大鼠心肌梗死面积;苏木素-伊红染色检测各组心肌组织病理学变化...

Objectives:To investigate the effect of diosgenin on apoptosis in rats with myocardial ischemia-reperfusion injury(MIRI),and analyze its effect on the signaling pathway of NOD-Like receptor protein 3(NLRP3)/cysteinyl aspartate specific proteinase-1(Caspase-1).Methods:The rat model of MIRI was established by ligation of left anterior descending coronary artery.72 rats with successful modeling were randomly divided into MIRI group,low-dose diosgenin group(50 mg/kg),medium-dose diosgenin group(75 mg/kg)and high-dose diosgenin group(100 mg/kg),with...