期刊论文

Xiang, Qiong;Liu, LS

中文

生物化学与生物物理进展

1000-3282

2024

51

4

944-958

10.16476/j.pibb.2023.0300

National Natural Science Foundation of China [81370376]; Natural Science Foundation of Hunan Province [2018JJ2343]

本校为第一且通讯机构

目的 阿尔茨海默病(Alzheimer's disease,AD)是多种危险因素引起的中枢神经系统退行性疾病,其中神经细胞凋亡是其主要病理基础之一.高脂血症是AD发生的高危因素,可导致脑组织内氧化低密度脂蛋白(oxidized lowdensity lipoprotein,ox-LDL)水平增高.前蛋白转化酶枯草溶菌素 9(proprotein convertase subtilisin kexin type 9,PCSK9)是一个与血脂代谢密切相关的蛋白酶,但有研究显示其与AD发生可能相关.本研究旨在探索PCSK9在介导ox-LDL促神经细胞凋亡中的作用及其机制,进一步阐述高脂血症导致AD等神经退行性疾病的发生机制.方法 首先用不同浓度ox-LDL(0、25、50、75、100mg/L)处理PC12细胞24h,油红...

Obiective Alzheimer's disease (AD) is a degenerative disease of the central nervous system (CNS)caused by a variety of risk factors. There are various pathological changes, but apoptosis of the neurological meridian cells is one of the most important pathological bases. Hyperlipidemia is a high-risk factor for the development of AD, which can lead to increased levels of oxidized low-density lipoprotein (ox-LDL) in brain tissues. PCSK9 is a protease closely related to lipid metabolism, but studies have shown that it may be related to the development of AD. LRP1 is abundantly expressed in neuron...