Alzheimer’s disease (AD), a serious degenerative disease of the central nervous system, is the most common cause of dementia in the elderly. Its etiology has not yet been elucidated. ATP-binding cassette transporter A7 (ABCA7) has a high level expression in the brain. Since the genome-wide association studies identified ABCA7 as a risk gene for AD, more and more evidence from in vitro, in vivo, and human-based studies has confirmed that ABCA7 is one of the most important risk genes for early-onset and late-onset AD. ABCA7 mediates phospholipid...
