期刊论文

Circular RNA and Its Research Status and Research Strategies in Gastric Cancer

Zhang Zhi-Wei

中文

生物化学与生物物理进展

1000-3282

2019

46

3

238-247

10.16476/j.pibb.2018.0216

Hunan Provincial Groundbreaking Platform Open Fund of University of China [12K094]; Doctoral Research Fund of University of South China [2016XQD21]; Student Research Learning and Innovative Experimental Project of University of South China [2016NH055XJXZ, 2017 XJXZ 030]; Hunan Provincial Key Subject Fund of Basic Medical Sciences at University of South China; Yueyang Maternal and Child Health Hospital Horizontal Cooperation Project [2018KHX43]

本校为第一且通讯机构

环状RNA (circRNA)是一种共价闭合的非编码RNA,可以调节真核生物中的基因表达.最近应用高通量RNA测序和生物信息学方法揭示人类细胞中存在大量circRNA.许多circRNA具有一定的组织和时序特异性,且与生理发育和各种肿瘤等疾病密切相关. circRNA被证明在细胞质中富集和稳定,表明其具有作为肿瘤生物标志物的潜力.胃癌(gastric carcinoma,GC)是一种常见的恶性肿瘤,在全球癌症相关死亡原因中排第3位.尽管该疾病在诊断和治疗方面取得了许多进展,但GC患者的预后仍然很差,大多数国家的5年总生存率低于30%.因此,寻找能调节GC发生发展和评估预后的新分子机制和治疗靶标至关重要.近年来circRNA在胃癌中的研究...

Circular RNA (circRNA) is a type of covalently closed non-coding RNA diat may regulate gene expression in eukaryotes. The recent application of high-throughput RNA sequencing and bioinformatics approaches has revealed a large number of circRNAs in human cells. Emerging evidence indicates that many circRNAs have tissue and timing specificity and are linked to physiological development and various diseases. circRNAs have also been shown to be enriched and stable in extracellular fluid, indicating die potential of circRNAs as cancer biomarkers. Ga...