期刊论文

microRNAs Act as Regulators of Autophagy in Cardiovascular Disease

Wang Zuo

中文

生物化学与生物物理进展

1000-3282

2018

45

11

1115-1125

10.16476/j.pibb.2018.0098

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81070221]; Innovative Research Team for Science and Technology in Higher Educational Institutions of Hunan Province; Construct Program of the Key Discipline in Hunan Province [15C1201]

本校为第一且通讯机构

自噬作为一种进化上高度保守的细胞降解途径,其调节异常与心血管疾病的发生、发展密切相关.研究显示,在心血管系统中,基础水平自噬对维持心肌正常收缩和传导至关重要,而在缺血/再灌注损伤和心力衰竭等心血管病理状态下,自噬水平明显增强.细胞自噬是一种多基因参与的复杂过程,近年来越来越多的证据表明,microRNAs（miRNAs）在心血管系统发育、正常生理功能维持以及不同心血管疾病（cardiovascular disease,CVDs）自噬中具有重要调节作用.本文通过对miRNAs与CVDs自噬调节方面的进展进行归纳,针对miRNAs对CVDs自噬的潜在机制进行总结,望为心血管疾病的诊断和治疗提供新的方向.

Autophagy is an evolutionarily conserved cellular degradation program. Abnormalities in autophagy are directly linked to human ailments. In the cardiovascular system, autophagy is essential for maintaining normal contraction and conduction at low basal levels under physiological conditions. Meanwhile, under pathological conditions, such as ischemia/reperfusion injury and heart failure, autophagy is enhanced. Accumulating evidence shows that microRNA plays a crucial role in autophagy in the cardiovascular system, including cardiac development, maintenance of normal physiological functions, and ...