期刊论文

The Role of apoA-Ⅰ's α-Helix in Cholesterol Efflux

Mo Zhong-Cheng;Tang Chao-Ke

中文

生物化学与生物物理进展

1000-3282

2018

45

6

629-636

10.16476/j.pibb.2018.0008

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81770461]

本校为通讯机构

Since the inverse relationship between the levels of apoA-玉 in plasma and the risk of cardiovascular disease is derived from the atherosclerosis (AS). Lipid apoA-玉 formation of high-density lipoprotein(HDL), which by promoting reverse cholesterol transport (RCT) helps cholesterol efflux. 琢-Helix plays an important role in cholesterol efflux, it’s the acceptor of lipid on apoA-玉. The mimic peptides of apoA-玉 have similar structure with 琢-helix, and they can inhibit the development of AS by different ways. This review focuses on the effect...

Since the inverse relationship between the levels of apoA- I in plasma and the risk of cardiovascular disease is derived from the atherosclerosis (AS). Lipid apoA- I formation of high-density lipoprotein(HDL), which by promoting reverse cholesterol transport (RCT) helps cholesterol efflux. alpha-Helix plays an important role in cholesterol efflux, it's the acceptor of lipid on apoA- I. The mimic peptides of apoA- I have similar structure with alpha-helix, and they can inhibit the development of AS by different ways. This review focuses on the effects of alpha-helix of apoA- I in cholesterol ef...