期刊论文

Advances of Proteins Mediated Cholesterol Transport in Macrophages

Mo Zhong-Cheng

中文

生物化学与生物物理进展

1000-3282

2017

44

2

139-147

10.16476/j.pibb.2016.0282

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81670401]; Natural Science Foundation of Hunan ProvinceNatural Science Foundation of Hunan Province [2016JJ6133]; College Students' Research Learning and Innovative Experiment Plan in University of South China [2016NH053XJXZ]; Zhengxiang Scholar (Xiangyang Tang) Program in University of South China

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动脉粥样斑块中泡沫细胞的形成与巨噬细胞胆固醇的转运密切相关,巨噬细胞胆固醇转运是胆固醇逆转运中的一个重要过程,它可清除外周组织过多的胆固醇,对维持细胞内胆固醇稳定、延缓动脉粥样硬化的发生发展有着重要意义.这个过程涉及到许多转运相关蛋白的作用,如三磷酸腺苷结合盒转运体A_1/G_1、载脂蛋白A-Ⅰ、胆固醇脂转运蛋白、卵磷脂胆固醇酰基转移酶等.本文就巨噬细胞胆固醇转运过程中相关蛋白的作用做一综述,以期为动脉粥样硬化相关疾病的防治研究提供新的思路.

The formation of foam cells in atherosclerotic plaques is closely related to the cholesterol transport of macrophages, which is an important process in reverse cholesterol transport. The cholesterol transport is key procedure for eliminating excess cholesterol from peripheral tissue, maintaining cholesterol homeostasis and delaying the development of atherosclerosis. The cholesterol transport of macrophages is mediated by multiple proteins, such as ATP binding cassette transporter A1/G1, apolipoprotein A-I, cholesteroyl ester transfer protein a...