期刊论文

Yin Kai

中文

生物化学与生物物理进展

1000-3282

2015

42

7

606-615

10.16476/j.pibb.2015.0060

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81100213, 81470569]

本校为第一且通讯机构

内皮-间质转化（endothelial-to-mesenchymal transition,End MT）属于上皮-间质转化（epithelial-to-mesenchymal transition,EMT）的特殊类型,是内皮细胞在多种刺激因素作用下向间充质细胞转化的过程,在此过程中内皮细胞逐渐失去其形态和功能,获得增殖、迁移和合成胶原等间充质细胞表型特点.近来研究发现,内皮-间质转化在内皮功能调节,心肌、血管及瓣膜的发育和结构重塑等方面发挥着关键的作用,提示其在心血管疾病领域具有重要的研究意义.本文对内皮-间质转化的特点、功能、调节机制以及在心血管系统发育、心肌纤维化、肺动脉高压和动脉粥样硬化性血管重构等心血管疾病中的作用做一综述,以期为...

Endothelial-to-mesenchymal transition (EndMT) is a parallel process of epithelial-to-mesenchymal transition (EMT), during which endothelial cells down-regulate the endothelial cells markers and acquire the phenotype of mesenchymal cells including proliferation, migration and collagen synthesize. Recent studies have shown that EndMT plays crucial physiological and pathophysiological roles in regulation of endothelial function, the development and structural remodel of cardiac muscle, cardiac valve and blood vessels. In this review, we summary the function and the regulation of the EndMT, and th...