期刊论文

Yi Guang-Hui

中文

生物化学与生物物理进展

1000-3282

2015

42

9

788-795

10.16476/j.pibb.2015.0109

National Natural Sciences Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81100211, 81270360]; Scientific Research Foundation for Doctor in University of South China [2012XQD27]; Construct Program of The Key Discipline in Hunan Province (Basic Medicine Sciences in University of South China, Xiangjiaofa) [[2011]76]; Construct Program of Innovation Team in University of South China

本校为第一且通讯机构

高密度脂蛋白（HDL）生物合成是一个有多种膜蛋白和胞质蛋白参与的复杂过程,载脂蛋白A-Ⅰ（apo A-Ⅰ）是HDL中最主要的结构和功能蛋白,它能活化卵磷脂胆固醇脂酰基转移酶（LCAT）,贫脂apo A-Ⅰ也是巨噬细胞中三磷酸腺苷结合盒转运体A1（ABCA1）介导的胆固醇流出的重要接受体.因此,apo A-Ⅰ在HDL及胆固醇代谢中的作用至关重要,它赋予了HDL多种抗动脉粥样硬化活性.本文主要就HDL生物合成及apo A-Ⅰ在其中的作用作一综述,以期为揭示HDL的代谢机制提供新思路.

The biogenesis of high density lipoproteins (HDL) is a complex process and involves several membrane proteins and plasma proteins. apoA- I is the major structural and functional protein in HDL. apoA- I can activate lecithin/cholesterol acyltransferase (LCAT) and poor-lipid apoA- I is the important receptor for ATP-binding cassette transporter A1 (ABCA1)-mediated efflux of cholesterol in macrophages. So, apoA- I plays an important role in the metabolism of HDL and cholesterol and endows HDL with multiple anti-atherogenic activities. This review focuses on the roles of apoA- I in biogenesis of H...