期刊论文

He Ping-Ping

中文

生物化学与生物物理进展

1000-3282

2014

41

4

317-323

10.3724/SP.J.1206.2013.00139

国家自然科学基金资助项目(81170278,81070220,81270269,30770689);湖南省科学技术发展计划资助项目(2013FJ3027);grants from The National Natural Science Foundation of China(81170278,81070220,81270269,30770689);The Hunan Provincial Science and Technology Department(2013FJ3027)

本校为第一且通讯机构

三磷酸腺苷结合盒转运体A1(ATP binding cassette transporter A1, ABCA1)在脑组织中广泛表达, 它将脑细胞内胆固醇转运给载脂蛋白E(apolipoprotein E, apoE)及载脂蛋白A1(apolipoprotein A1, apoA-Ⅰ)形成高密度脂蛋白(high density lipoprotein, HDL), 从而调控脑内胆固醇平衡.研究表明, ABCA1与胆固醇代谢相关脑疾病存在密切联系, 包括阿尔茨海默病(Alzheimer's disease, AD)、创伤性脑损伤(traumatic brain injury, TBI)及脑梗死.虽然近来在ABCA1与相关脑疾病的研究取得了一些进展, 但仍存在许多问题尚未阐明.本文对ABCA1在各种相关脑疾病发生发展中的作用做一综述, 期望为相关脑疾病的治疗...

ATP-binding cassette transporters A1 (ABCA1) is expressed widely in the brain tissues. It transports intracellular cholesterol to apolipoprotein E (apoE) and apolipoprotein A1 (apoA- I) to form high-density lipoprotein, thus regulates the balance of brain cholesterol. Research has shown, there is a close relationship between ABCA1 and brain diseases about cholesterol metabolism, including Alzheimer's disease(AD), traumatic brain injury(TBI) and Cerebral infarction. Recently, there are some research progresses about ABCA1 and brain disease, but there are still many problems that has not been cl...