期刊论文

Chen Lin-Xi

中文

生物化学与生物物理进展

1000-3282

2013

40

12

1177-1185

10.3724/SP.J.1206.2012.00623

国家自然科学基金(81270420,30901577)资助项目和湖南省自然科学基金省市联合(衡阳)基金重点项目(12JJ8013).This work was supported by grants from The National Natural Science Foundation of China(81270420,30901577);Heng Yang Joint Funds of Hunan Provincial Natural Science Foundation of China(12JJ8013)

本校为第一且通讯机构

自噬(autophagy)是细胞利用溶酶体降解自身受损的细胞器和大分子物质的过程,在稳定细胞内环境中发挥着重要作用.研究发现,自噬影响血管功能,与血管疾病的病理生理进程密切相关.本文从自噬对血管功能的影响,与血管相关疾病(如动脉粥样硬化、腹主动脉瘤、肺动脉高压、糖尿病血管并发症等)的关系及药物对血管壁细胞自噬的调控进行综述,希望从自噬的角度来了解血管的功能和病变及一些疾病的发生发展进程,为治疗血管相关疾病提供新的思路.

Autophagy which is a process that damaged organelles and cellular proteins are degraded by lysosomes plays a critical role in cellular homeostasis. Previous studies have demonstrated that autophagy influenced the vascular function, even involved in the pathophysiology of vascular diseases. In this review we focus on the effect of autophagy on the vascular function and vascular diseases such as atherosclerosis, abdominal aortic aneurysm, pulmonary hypertension and diabetes mellitus. Moreover, we try to provide a new way...