期刊论文

Tang Chao-Ke

中文

生物化学与生物物理进展

1000-3282

2013

40

6

510-519

10.3724/SP.J.1206.2012.00419

国家自然科学基金资助项目(81170278,81070220).This work was supported by a grant from The National Natural Science Foundation of China (81170278,81070220)

本校为第一且通讯机构

三磷酸腺苷结合盒转运体A1（ABCA1）具有介导细胞内脂质流出,维持细胞脂质稳态的功能.新生的ABCA1必须经过胞内运输和各种化学修饰等过程,最终成为具有功能的成熟转运体,才能行使其转运脂质的功能,因此,ABCA1在胞内的运输过程和正确质膜定位对其介导胆固醇流出的功能至关重要.目前ABCA1相关研究主要集中于脂质转运方面,并提出各种胆固醇流出机制的模型,如通道转运模型、蘑菇状突起模型和胞吞-胞吐转运模型等.最近研究显示,ABCA1还具有调节质膜脂筏结构、参与免疫和炎症调节等新功能.本文主要针对ABCA1的胞内运输过程以及各种功能做一综述,以期为动脉粥样硬化相关疾病提供新的治疗靶点和途径.

ATP-binding cassette transporter 1 (ABCA1) mediated lipid efflux and evolved to maintain cholesterol homeostasis. Newborn ABCA1 should through intracellular transport and chemical modification, ultimately being a mature functional transporter with its function of lipid transport. The intracellular transport and correct localization of ABCA1 plays an important role in its function. ABCA1 researches focused on the lipid transport, and proposed the model of the various cholesterol efflux mechanisms, such as channel transport model, mushroom-like protuberances model and retroendocytosis model. Rec...