Hydrogen sulfide antagonizes formaldehyde-induced ferroptosis via preventing ferritinophagy by upregulation of GDF11 in HT22 cells

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成果类型：

期刊论文

作者：

Tang, Yu-Hui;Wu, Lei;Huang, Hong-Lin;Zhang, Pan-Pan;Zou, Wei;...

通讯作者：

Tang, Xiao-Qing;Tang, YY

作者机构：

[Tang, Yu-Hui] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Clin Lab Med, Hengyang 421001, Hunan, Peoples R China.

[Huang, Hong-Lin; Wu, Lei] Univ South China, Inst Pharm & Pharmacol, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.

[Zhang, Pan-Pan; Tang, Yi-Yun; Tang, Xiao-Qing; Tang, XQ] Univ South China, Inst Neurosci, Hengyang Med Sch, 28 W Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

[Tang, Xiao-Qing] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Neurol, Hengyang 421001, Hunan, Peoples R China.

[Zou, Wei] Univ South China, Affiliated Nanhua Hosp, Dept Neurol, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Tang, YY ; Tang, XQ] U

Univ South China, Inst Neurosci, Hengyang Med Sch, 28 W Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

Ferritinophagy;Ferroptosis;Formaldehyde;Growth differentiation factor 11;Hydrogen sulfide

期刊：

Toxicology

ISSN：

0300-483X

年：

2023

卷：

491

页码：

153517

DOI：

10.1016/j.tox.2023.153517

基金类别：

statement This research was funded by the National Natural Science Foundation of China (grant number 82271559), the Scientific Research Fund of Hunan Provincial Education Department (grant number 21B0429), and the University of South China Graduate Research Innovation Program (grant number 223YXC028).

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

Formaldehyde (FA) has neurotoxic characteristics and causes neurodegenerative disease. Our previous study demonstrated the neuroprotective effects of hydrogen sulfide (H(2)S) on FA-induced neurotoxicity in HT22 cells. Emerging evidence have supported that ferroptosis is involved in FA-induced neurotoxicity. To understand the mechanism of the protection of H(2)S against FA-induced neurotoxicity, this study explored the regulatory effect of H(2)S on FA-induced ferroptosis and the underlying mechanisms. The researcher found that H(2)S (100, 200, a...

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Hydrogen sulfide antagonizes formaldehyde-induced ferroptosis via preventing ferritinophagy by upregulation of GDF11 in HT22 cells

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