Hydrogen sulfide antagonizes chronic restraint stress-induced depressive-like behaviors via upregulation of adiponectin

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成果类型：

期刊论文

作者：

Tian, Qing;Chen, Lei;Luo, Bang;Wang, Ai-Ping*;Zou, Wei;...

通讯作者：

Tang, Xiao-Qing;Wang, Ai-Ping

作者机构：

[Tang, Xiao-Qing; Chen, Lei; Luo, Bang; Zou, Wei; You, Yong; Zhang, Ping; Tian, Qing] Univ South China, Inst Neurosci, Coll Med, Hengyang, Peoples R China.

[Wang, Ai-Ping; Chen, Lei; Zou, Wei; Zhang, Ping] Univ South China, Inst Clin Res, Affiliated Nanhua Hosp, Hengyang, Peoples R China.

[Tang, Xiao-Qing; Luo, Bang; You, Yong] Univ South China, Inst Clin Res, Affiliated Hosp 1, Hengyang, Peoples R China.

通讯机构：

[Tang, Xiao-Qing; Wang, Ai-Ping] U

Univ South China, Inst Neurosci, Coll Med, Hengyang, Peoples R China.

Univ South China, Inst Clin Res, Affiliated Nanhua Hosp, Hengyang, Peoples R China.

Univ South China, Inst Clin Res, Affiliated Hosp 1, Hengyang, Peoples R China.

语种：

英文

关键词：

adiponectin;autophagy;chronic restraint stress;depressive-like behavior;hydrogen sulfide;synapse formation

期刊：

FRONTIERS IN PSYCHIATRY

ISSN：

1664-0640

年：

2018

卷：

期：

AUG

页码：

399

DOI：

10.3389/fpsyt.2018.00399

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81671057, 81371485]; Major Research Topics of the Health and Family Planning Commission of Hunan province [A2017020]; Key Projects of the Education Department of Hunan province [17A187]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Backgroud: Chronic restraint stress (CRS) induces depressive-like behaviors in rodents, which involves dysregulation of hippocampal synapse formation and excessive autophagy. Adiponectin has antidepressant activity. Hydrogen sulfide (H 2 S) is a novel gasotransmitter. The present work was to investigate whether H 2 S antagonizes CRS-induced depressive-like behaviors in rats and to explore whether its potential mechanism involves ameliorated synaptic and autophagic dysregulation by upregulation of adiponectin. Methods: Depressive-like behavior w...

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Hydrogen sulfide antagonizes chronic restraint stress-induced depressive-like behaviors via upregulation of adiponectin

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