Hydrogen sulfide antagonizes homocysteine-induced neurotoxicity in PC12 cells

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成果类型：

期刊论文

作者：

Tang, Xiao-Qing*;Shen, Xin-Tian;Huang, Yi-E;Ren, Yan-Kai;Chen, Rong-Qian;...

通讯作者：

Tang, Xiao-Qing

作者机构：

[Ren, Yan-Kai; Chen, Rong-Qian; Tang, Xiao-Qing; Hu, Bi; He, Jian-Qin; Shen, Xin-Tian; Yin, Wei-Lan] Univ S China, Dept Physiol, Coll Med, Hengyang 421001, Hunan, Peoples R China.

[Jiang, Zhi-Sheng] Univ S China, Dept Pathophysiol, Coll Med, Hengyang 421001, Hunan, Peoples R China.

[Shen, Xin-Tian; Huang, Yi-E] Huaihua Med Coll, Dept Physiol, Huaihua 418000, Hunan, Peoples R China.

[Xu, Jin-Hua] Univ S China, Lab Ctr Biochem & Mol Biol, Hengyang 421001, Hunan, Peoples R China.

[Tang, Xiao-Qing] Univ S China, Dept Physiol, Coll Med, 28 W Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Tang, Xiao-Qing] U

Univ S China, Dept Physiol, Coll Med, 28 W Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

Bcl-2;Homocysteine;Hydrogen sulfide;Mitochondrial membrane potential;Neuroprotection;Reactive oxygen species

期刊：

Neuroscience Research

ISSN：

0168-0102

年：

2010

卷：

期：

页码：

241-249

DOI：

10.1016/j.neures.2010.07.2039

基金类别：

Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [30770740]; Natural Science Foundation of Hunan Province, ChinaNatural Science Foundation of Hunan Province [06JJ2074]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2005038233]; Department of Science and Technology, Hunan ProvinceDepartment of Science & Technology (India) [05FJ3039]; Research Foundation of Education Bureau of Hunan Province [06C700]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

Hydrogen sulfide (H(2)S) has been shown to protect neurons against oxidative stress. Lower levels of H(2)S as well as accumulation of homocysteine (Hcy), a strong risk of Alzheimer's disease (AD), are reported in the brains of AD patients. The aim of present study is to explore the protection of H(2)S against Hcy-induced cytotoxicity and apoptosis and the molecular mechanisms underlying in PC12 cells. We show that sodium hydrosulfide (NaHS), a H(2)S donor, protects PC12 cells against Hcy-mediated cytotoxicity and apoptosis by preventing both the loss of mitochondrial membrane potential (MMP) a...

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Hydrogen sulfide antagonizes homocysteine-induced neurotoxicity in PC12 cells

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