Social isolation produces anxiety-like behaviors and changes PSD-95 levels in the forebrain

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成果类型：

期刊论文

作者：

Zhang, Yong;Zu, Xuyu;Luo, Weishi;Yang, Hongwei;Luo, Guoxuan;...

通讯作者：

Tang, Shengsong

作者机构：

[Tang, Shengsong; Yang, Hongwei; Luo, Guoxuan; Zhang, Mengxia; Zhang, Yong] Univ S China, Inst Pharm & Pharmacol, Hengyang 421001, Hunan, Peoples R China.

[Tang, Shengsong] Hunan Univ Arts & Sci, Coll Life Sci, Changde 415000, Hunan, Peoples R China.

[Luo, Weishi; Yang, Hongwei; Luo, Guoxuan; Zhang, Yong] Guangdong 2 Prov Peoples Hosp, Dept Neurosurg, Guangzhou 510317, Guangdong, Peoples R China.

[Zu, Xuyu] Univ S China, Affiliated Hosp 1, Inst Clin Med, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Tang, Shengsong] H

Hunan Univ Arts & Sci, Coll Life Sci, Changde 415000, Hunan, Peoples R China.

语种：

英文

关键词：

brain protein;postsynaptic density protein 95;amygdaloid nucleus;animal experiment;animal model;animal tissue;anxiety;article;controlled study;forebrain;frontal cortex;hippocampus;hypophagia;male;mouse;nonhuman;priority journal;protein expression;social isolation;Animals;Anxiety;Behavior, Animal;Eating;Exploratory Behavior;Guanylate Kinase;Male;Membrane Proteins;Mice;Mice, Inbred C57BL;Prosencephalon;Social Isolation

期刊：

Neuroscience Letters

ISSN：

0304-3940

年：

2012

卷：

514

期：

页码：

27-30

DOI：

10.1016/j.neulet.2012.02.043

基金类别：

This project was funded by supported by a grant from the National Natural Science Foundation of China ( 30270684 ), the Natural Foundation of Hunan Province ( 09JJ3060 ), the Key Scientific Research Project of Department of Hunan Education ( 10A087 ), and Hunan School of Higher Learning Foundation of Science and Technology Innovation Platform ( 09K072 ), and the Scientific Research Project of Guangdong Province (2009B030801240).

机构署名：

本校为第一机构

院系归属：

医学院

药学与生物科学学院

摘要：

Isolation rearing induces profound behavioral and neurochemical abnormalities in rodents. However there have been many controversies with its anxiogenic-like effects using models like elevated-plus maze. In the current study we aimed to address this by using one novelty-based anxiety paradigm that has been largely overlooked in previous isolation rearing studies. We found that eight-week isolation rearing produced potent anxiogenic-like effects in novelty-induced hypophagia test in mice. We also demonstrated PSD-95 levels were elevated in the h...

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Social isolation produces anxiety-like behaviors and changes PSD-95 levels in the forebrain

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