期刊论文

Zhang, Chi;Huang, Liang

英文

Clinica Chimica Acta

0009-8981

2020

508

228-233

10.1016/j.cca.2020.05.033

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81100106, 81670424]; Hunan Provincial Natural Science Foundation of ChinaNatural Science Foundation of Hunan Province [2018JJ2345]; International Joint Laboratory for Arteriosclerotic Disease Research of Hunan Province [2018WK4031]; Outstanding Youth Project - Scientific Research Fund of Hunan Provincial Education DepartmentHunan Provincial Education Department [19B478]; Scientific Research Foundation for Doctor of University of South China [2012XQD37, 2017XQD04]; Scientific Research Foundation for the Returned Overseas Scholars of University of South ChinaScientific Research Foundation for the Returned Overseas Chinese Scholars [2017XQD29]; Hunan Provincial College Students Research Study and Innovative Experiment Project [2017-1039, 2018-470, 2019-2261]

本校为第一且通讯机构

Atherosclerosis (AS) is the pathophysiologic basis of many cardiovascular diseases. A number of studies have shown that post-translational modification (PTM) contributes to the initiation and progression of AS. For example, recent studies found that SUMOylation, ie, small ubiquitin-like modifier (SUMO) conjugation to target substrate proteins, was involved in AS. This PTM appears related to endothelial cell dysfunction (ECD), dyslipidemia and vascular smooth muscle cell (VSMC) proliferation. This review focuses on the molecular effects of SUMOylation in the initiation and progression of AS, in...