Silver nanoparticles induced oxidative and endoplasmic reticulum stresses in mouse tissues: implications for the development of acute toxicity after intravenous administration

首页 > 成果 > 详情

认领

导出

下载 Link by 馆藏

反馈

作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Chen, Rui;Zhao, Lin;Bai, Ru;Liu, Ying;Han, Liping;...

通讯作者：

Long, Dingxin;Chen, Chunying

作者机构：

[Long, Dingxin; Chen, Feng; Chen, Rui] Univ South China, Sch Publ Hlth, Hengyang 421001, Peoples R China.

[Liu, Ying; Xu, Zhifang; Zhao, Lin; Chen, Chunying; Bai, Ru; Chen, Rui; Han, Liping] Natl Ctr Nanosci & Technol China, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China.

[Liu, Ying; Xu, Zhifang; Zhao, Lin; Chen, Chunying; Bai, Ru; Chen, Rui; Han, Liping] Natl Ctr Nanosci & Technol China, CAS Ctr Excellence Nanosci, Beijing 100190, Peoples R China.

[Autrup, Herman] Aarhus Univ, Dept Publ Hlth, Bartholins Alle 2, DK-8000 Aarhus C, Denmark.

通讯机构：

[Long, Dingxin] U

[Chen, Chunying] N

Univ South China, Sch Publ Hlth, Hengyang 421001, Peoples R China.

Natl Ctr Nanosci & Technol China, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China.

Natl Ctr Nanosci & Technol China, CAS Ctr Excellence Nanosci, Beijing 100190, Peoples R China.

语种：

英文

期刊：

TOXICOLOGY RESEARCH

ISSN：

2045-452X

年：

2016

卷：

期：

页码：

602-608

DOI：

10.1039/c5tx00464k

基金类别：

Ministry of Science and Technology of ChinaMinistry of Science and Technology, China [2012CB934003]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21477029, 21320102003, 21277037, 21403043, 21277080]; Chinese Academy of SciencesChinese Academy of Sciences [XDA09040400]; Beijing Natural Science FoundationBeijing Natural Science Foundation [2152037]; Beijing Key Laboratory of Environmental Toxicology [2015HJDL01]; Major Project of the National Social Science Fund [12ZD117]; National Science Fund for Distinguished Young ScholarsNational Natural Science Foundation of China (NSFC)National Science Fund for Distinguished Young Scholars [11425520]

机构署名：

本校为第一且通讯机构

院系归属：

公共卫生学院

摘要：

Concerns have arisen about the health and environmental impacts of the increasing commercial use of silver nanoparticles (AgNPs). However, the toxic mechanisms and target tissues of AgNPs have not been fully defined. In this paper, we investigated the tissue toxicity of mice after intravenous administration of AgNPs at a single-dose of 0.2, 2 or 5 mg per kg (body weight), respectively. Biodistribution, endoplasmic reticulum stress, and oxidative stress were examined in mouse organs at eight hours after exposure. Stress markers, e.g. HSP70, BIP, p-IRE1, p-PERK, chop and xbp-1s proteins/genes, w...

反馈

产权有误：本人成果被他人认领

数据有误：数据基本信息有误

归属有误：成果的院系归属、机构署名归属有误

其他原因：

验证码：

看不清楚，换一个

确定

取消

成果认领

标题：

用户	作者	通讯作者	--
	请选择	请选择	--

确定

取消

Silver nanoparticles induced oxidative and endoplasmic reticulum stresses in mouse tissues: implications for the development of acute toxicity after intravenous administration

反馈

成果认领

提示

该栏目需要登录且有访问权限才可以访问