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circRNA-miRNA-mRNA in breast cancer

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成果类型:
期刊论文
作者:
Zhang, Meilan;Bai, Xue;Zeng, Xuemei;Liu, Jiangrong;Liu, Feng*;...
通讯作者:
Liu, Feng;Zhang, Zhiwei
作者机构:
[Zhang, Meilan; Zhang, Zhiwei; Bai, Xue; Liu, Feng; Zhang, ZW; Zeng, Xuemei; Liu, Jiangrong] Univ South China, Hengyang Med Coll, Canc Res Inst, Key Lab Canc Cellular & Mol Pathol Hunan Prov, Hengyang 421001, Hunan, Peoples R China.
通讯机构:
[Liu, F; Zhang, ZW] U
Univ South China, Hengyang Med Coll, Canc Res Inst, Key Lab Canc Cellular & Mol Pathol Hunan Prov, Hengyang 421001, Hunan, Peoples R China.
语种:
英文
关键词:
Breast cancer;circRNA;miRNA;mRNA
期刊:
Clinica Chimica Acta
ISSN:
0009-8981
年:
2021
卷:
523
页码:
120-130
基金类别:
When circRNAs and miRNAs have binding sites, they can bind competitively, and circRNAs act as sponges, thus affecting miRNA regulation of target genes. The role of circRNA-miRNA-mRNA regulatory networks in various tumours has been extensively reported. In BC, the regulatory network is also involved in many biological processes, such as inhibition of tumorigenesis, invasion and migration. Table 2 lists circRNAs, miRNAs and target mRNAs that inhibit tumours and their roles in the progression of
机构署名:
本校为第一且通讯机构
院系归属:
医学院
摘要:
Among cancers, breast cancer has the highest incidence rate among women and poses a tremendous threat to women's health. Messenger RNA (mRNA), microRNA (miRNA) and circular RNA (circRNA) play vital roles in the progression of breast cancer through a variety of biological effects and mechanisms. Recently, the regulatory network formed by circRNAs, miRNAs and mRNAs has piqued attention and garnered interest. CircRNAs bind to miRNAs through a regulatory mechanism in which endogenous RNAs compete to indirectly regulate the expression of mRNA corres...

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