Cytosolic Release of Mitochondrial DNA and Associated cGAS Signaling Mediates Radiation-Induced Hematopoietic Injury of Mice

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成果类型：

期刊论文

作者：

Guan, Hua;Zhang, Wen;Xie, Dafei;Nie, Yuehua;Chen, Shi;...

通讯作者：

Shanshan Gao<&wdkj&>Hua Guan

作者机构：

[Guan, Hua; Zhou, Pingkun; Chen, Shi; Zhang, Wen; Sun, Xiaoya] Univ South China, Hengyang Med Sch, Hengyang 421001, Peoples R China.

[Nie, Yuehua; Liu, Xiaochang; Xie, Dafei; Bai, Chenjun; Huang, Xin; Zhao, Hongling; Guan, Hua; Zhou, Pingkun; Chen, Shi; Zhang, Wen; Gao, Shanshan; Sun, Xiaoya] Beijing Inst Radiat Med, Dept Radiat Biol, Beijing Key Lab Radiobiol, Beijing 100850, Peoples R China.

[Nie, Yuehua; Huang, Bo; Zhou, Pingkun; Chen, Shi; Sun, Xiaoya] Univ South China, Sch Publ Hlth, Hengyang 421001, Peoples R China.

[Wang, Hua] Beijing Inst Radiat Med, Dept Expt Hematol & Biochem, Beijing Key Lab Radiobiol, Beijing 100850, Peoples R China.

通讯机构：

[Shanshan Gao; Hua Guan] A

Authors to whom correspondence should be addressed.<&wdkj&>Hengyang Medical School, University of South China, Hengyang 421001, China<&wdkj&>Beijing Key Laboratory for Radiobiology, Department of Radiation Biology, Beijing Institute of Radiation Medicine, Beijing 100850, China<&wdkj&>Authors to whom correspondence should be addressed.<&wdkj&>Beijing Key Laboratory for Radiobiology, Department of Radiation Biology, Beijing Institute of Radiation Medicine, Beijing 100850, China

语种：

英文

关键词：

mitochondrial DNA;bone marrow tissue;hematopoietic stem cells;radiation injury;non-target effect;cGAS signaling;inflammatory response;mice

期刊：

International Journal of Molecular Sciences

ISSN：

1422-0067

年：

2023

卷：

期：

页码：

4020-

DOI：

10.3390/ijms24044020

基金类别：

This study was supported by the National Natural Science Foundation of China (Grant No. 31870847; 82173466).

机构署名：

本校为第一机构

院系归属：

公共卫生学院

摘要：

Mitochondrion is an important organelle of eukaryotic cells and a critical target of ionizing radiation (IR) outside the nucleus. The biological significance and mechanism of the non-target effect originating from mitochondria have received much attention in the field of radiation biology and protection. In this study, we investigated the effect, role, and radioprotective significance of cytosolic mitochondrial DNA (mtDNA) and its associated cGAS signaling on hematopoietic injury induced by IR in vitro culture cells and in vivo total body irradiated mice in this study. The results demonstrated...

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Cytosolic Release of Mitochondrial DNA and Associated cGAS Signaling Mediates Radiation-Induced Hematopoietic Injury of Mice

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