Na+/H+ exchanger mediates TNF-alpha-induced hepatocyte apoptosis via the calpain-dependent degradation of Bcl-xL

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成果类型：

期刊论文

作者：

Liu, Zhan*;Wang, Shuangxi;Zhou, Huixin;Yang, Yuming;Zhang, Mingliang

通讯作者：

Liu, Zhan

作者机构：

[Yang, Yuming; Zhou, Huixin; Liu, Zhan] Hunan Normal Univ, Peoples Hosp Hunan Prov, Dept Gastroenterol, Affiliated Hosp 1, Changsha 410005, Hunan, Peoples R China.

[Wang, Shuangxi] Univ Oklahoma, Dept Med, Oklahoma City, OK USA.

[Zhang, Mingliang] Nanhua Univ, Affiliated Hosp 2, Dept Gastroenterol, Hengyang City, Hunan, Peoples R China.

[Liu, Zhan] Hunan Normal Univ, Peoples Hosp Hunan Prov, Dept Gastroenterol, Affiliated Hosp 1, 61 Liberat W Rd, Changsha 410005, Hunan, Peoples R China.

通讯机构：

[Liu, Zhan] H

Hunan Normal Univ, Peoples Hosp Hunan Prov, Dept Gastroenterol, Affiliated Hosp 1, 61 Liberat W Rd, Changsha 410005, Hunan, Peoples R China.

语种：

英文

关键词：

apoptosis;Bcl-xL;calpain;hepatocyte;Na+/H+ exchanger;tumor necrosis factor-alpha

期刊：

Journal of Gastroenterology and Hepatology

ISSN：

0815-9319

年：

2009

卷：

期：

页码：

879-885

DOI：

10.1111/j.1440-1746.2008.05715.x

基金类别：

Hunan Natural Science Department [06SK3069]; Hunan Education Department [B20005051]; Hunan Health Department, Changsha City, China [B2007139]

机构署名：

本校为其他机构

摘要：

Background and Aim: It is well known that tumor necrosis factor-α (TNF-α) induces hepatocyte apoptosis and contributes to liver diseases. However, the exact mechanisms are not well understood. Methods: In the present study, we reported that Na+/H+ exchanger (NHE) is involved in TNF-α-induced hepatocyte apoptosis. Results: TNF-α time dependently induced an increase in NHE activity in hepatocytes, but cariporide, an NHE inhibitor, blocked the TNF-α-induced increase of NHE activity in a dose-dependent manner. Increased NHE activity induced by...

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Na+/H+ exchanger mediates TNF-alpha-induced hepatocyte apoptosis via the calpain-dependent degradation of Bcl-xL

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