Integrating single-cell and spatial transcriptomics reveals endoplasmic reticulum stress-related CAF subpopulations associated with chordoma progression

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Zhang, Tao-Lan;Xia, Chao;Zheng, Bo-Wen;Hu, Hai-Hong;Jiang, Ling-Xiang;...

通讯作者：

Yan, Yi-Guo;Zou, MX

作者机构：

[Zhang, Tao-Lan; Hu, Hai-Hong; Zheng, Bo-Wen] Univ South China, Affiliated Hosp 1, Inst Clin Med, Hengyang Med Sch, Hengyang, Hunan, Peoples R China.

[Zhang, Tao-Lan] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Pharm, Hengyang, Peoples R China.

[Xia, Chao; Zou, Ming-Xiang; Yan, Yi-Guo] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Spine Surg, Hengyang, Peoples R China.

[Zheng, Bo-Wen] Peking Univ, Peoples Hosp, Musculoskeletal Tumor Ctr, Beijing, Peoples R China.

[Jiang, Ling-Xiang] Indiana Univ Sch Med, Melvin & Bren Simon Comprehens Canc Ctr, Dept Radiat Oncol, Indianapolis, IN USA.

通讯机构：

[Zou, MX ; Yan, YG] U

Univ South China, Affiliated Hosp 1, Dept Spine Surg, 69 Chuanshan Rd, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

chordoma progression;cancer-associated fibroblasts;endoplasmic reticulum stress;scRNA-seq;spatial transcriptomics

期刊：

NEURO-ONCOLOGY

ISSN：

1522-8517

年：

2024

卷：

期：

页码：

295-308

DOI：

10.1093/neuonc/noad173

基金类别：

We thank Alpha X Biotech Co., Ltd., Beijing, China for assistance with Multiplexed Quantitative Immunofluorescence.; Alpha X Biotech Co., Ltd.

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

BACKGROUND: With cancer-associated fibroblasts (CAFs) as the main cell type, the rich myxoid stromal components in chordoma tissues may likely contribute to its development and progression. METHODS: Single-cell RNA sequencing (scRNA-seq), spatial transcriptomics, bulk RNA-seq, and multiplexed quantitative immunofluorescence (QIF) were used to dissect the heterogeneity, spatial distribution, and clinical implication of CAFs in chordoma. RESULTS: We sequenced here 72 097 single cells from 3 primary and 3 recurrent tumor samples, as well as 3 nucleus pulposus samples as controls using scRNA-seq. ...

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Integrating single-cell and spatial transcriptomics reveals endoplasmic reticulum stress-related CAF subpopulations associated with chordoma progression

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