JQ1 as a BRD4 Inhibitor Blocks Inflammatory Pyroptosis-Related Acute Colon Injury Induced by LPS

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Chen, Ling;Zhong, Xiaolin;Cao, Wenyu;Mao, Mingli;Li, Wei;...

通讯作者：

Liu, Jianghua;Zu, Xuyu

作者机构：

[Zhong, Xiaolin; Mao, Mingli; Liu, Jianghua; Li, Menglin; Chen, Ling] Univ South China, Affiliated Hosp 1, Dept Endocrinol & Metab, Hengyang, Peoples R China.

[Cao, Wenyu; Li, Wei; Deng, Yincheng; Shi, Mengmeng; Yang, Hui] Univ South China, Hengyang Med Sch, Clin Anat & Reprod Med Applicat Inst, Hengyang, Peoples R China.

[Zhang, Yuan] Univ South China, Hengyang Med Sch, Dept Pathol, Hengyang, Peoples R China.

[Zu, Xuyu] Univ South China, Affiliated Hosp 1, Dept Tumor Res, Hengyang, Peoples R China.

通讯机构：

[Liu, Jianghua; Zu, Xuyu] U

Univ South China, Affiliated Hosp 1, Dept Endocrinol & Metab, Hengyang, Peoples R China.

Univ South China, Affiliated Hosp 1, Dept Tumor Res, Hengyang, Peoples R China.

语种：

英文

关键词：

Colon injury;BRD4;pyroptosis;JQ1;Endotoxemia

期刊：

FRONTIERS IN IMMUNOLOGY

ISSN：

1664-3224

年：

2021

卷：

页码：

609319

DOI：

10.3389/fimmu.2021.609319

基金类别：

Project of Hunan Health Committee [202110002229]; Natural Science Foundation of Hunan ProvinceNatural Science Foundation of Hunan Province [2019JJ50545]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81873651, 81901147]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Endotoxemia is a severe inflammation response induced by infection especially bacterial endotoxin translocation, which severely increases mortality in combination with acute colon injury. Bromodomain-containing protein 4 (BRD4) is an important Bromo and Extra-Terminal (BET) protein to participate in inflammatory responses. However, it is still unknown about the specific connection between BRD4 and inflammation-related pyroptosis in endotoxemia colon. Here, through evaluating the mucous morphology and the expression of tight junction proteins su...

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JQ1 as a BRD4 Inhibitor Blocks Inflammatory Pyroptosis-Related Acute Colon Injury Induced by LPS

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