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Copper complex with thiazole-modified tridentate ligand: synthesis, structural characterization, and anticancer activity in B16-F10 melanoma cells

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成果类型:
期刊论文
作者:
Wang, Bishu*;Zhong, Huishan;Huo, Jiawen;Wang, Tao;Wu, Fenglin;...
通讯作者:
Wang, Bishu;Du, Kejie
作者机构:
[Huo, Jiawen; Wang, Jinquan; Zhong, Huishan; Wu, Fenglin; Wang, Tao; Wang, Bishu; Feng, Tao] Guangdong Provincial Key Laboratory of Pharmaceutical Preparations Research and Evaluation
[Huo, Jiawen; Wang, Jinquan; Zhong, Huishan; Wu, Fenglin; Wang, Tao; Wang, Bishu; Feng, Tao] School of Bioscience and Biopharmaceutics, Guangdong Pharmaceutical University, Guangzhou, 510006, P. R. China. wangjinquan@gdpu.edu.cn
[Du, Kejie] School of Chemistry and Chemical Engineering, Laboratory of Protein Structure and Function, Hunan Key Laboratory for the Design and Application of Actinide Complexes, University of South China, Hengyang 421001, China. dukejie@usc.edu.cn
通讯机构:
[Wang, Bishu; Du, Kejie] S
School of Bioscience and Biopharmaceutics, Guangdong Pharmaceutical University, Guangzhou, 510006, P. R. China.
School of Chemistry and Chemical Engineering, Laboratory of Protein Structure and Function, Hunan Key Laboratory for the Design and Application of Actinide Complexes, University of South China, Hengyang 421001, China.
语种:
英文
期刊:
DALTON TRANSACTIONS
ISSN:
1477-9226
年:
2025
机构署名:
本校为通讯机构
院系归属:
化学化工学院
摘要:
Copper serves as a crucial trace element in various biological systems. Copper ions form complexes with different ligands, amplifying reactive oxygen species (ROS) levels and promoting intracellular ROS accumulation in multiple cancer cell types. In this study, a copper(II) complex, dichlorido[4-(5-bromothiazol-2-yl)-2,2'-bipyridine] copper(II) (Cu1), was synthesized using a terpyridine derivative as the ligand. Its structural configuration was confirmed through mass spectrometry and single-crystal X-ray diffraction analysis. The in vitro anticancer efficacy and mechanisms of Cu1 against B16-F...

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