A copper complex with a thiazole-modified tridentate ligand: synthesis, structural characterization, and anticancer activity in B16-F10 melanoma cells

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成果类型：

期刊论文

作者：

Wang, Bishu;Zhong, Huishan;Huo, Jiawen;Wang, Tao;Wu, Fenglin;...

通讯作者：

Feng, Tao;Wang, JQ;Du, KJ

作者机构：

[Huo, Jiawen; Wang, Jinquan; Zhong, Huishan; Wu, Fenglin; Wang, Tao; Wang, Bishu; Feng, Tao] Guangdong Pharmaceut Univ, Guangdong Prov Key Lab Pharmaceut Preparat Res & E, Guangzhou 510006, Peoples R China.

[Huo, Jiawen; Wang, Jinquan; Zhong, Huishan; Wu, Fenglin; Wang, Tao; Wang, Bishu; Feng, Tao] Guangdong Pharmaceut Univ, Sch Biosci & Biopharmaceut, Guangzhou 510006, Peoples R China.

[Du, Kejie] Univ South China, Sch Chem & Chem Engn, Lab Prot Struct & Funct, Hunan Key Lab Design & Applicat Actinide Complexes, Hengyang 421001, Peoples R China.

通讯机构：

[Wang, JQ ; Feng, T] G

[Du, KJ ] U

Guangdong Pharmaceut Univ, Guangdong Prov Key Lab Pharmaceut Preparat Res & E, Guangzhou 510006, Peoples R China.

Guangdong Pharmaceut Univ, Sch Biosci & Biopharmaceut, Guangzhou 510006, Peoples R China.

Univ South China, Sch Chem & Chem Engn, Lab Prot Struct & Funct, Hunan Key Lab Design & Applicat Actinide Complexes, Hengyang 421001, Peoples R China.

语种：

英文

期刊：

DALTON TRANSACTIONS

ISSN：

1477-9226

年：

2025

卷：

期：

页码：

14079-14092

DOI：

10.1039/d5dt01235j

基金类别：

National Natural Science Foundation of China [22277013]; National Natural Science Foundation of China

机构署名：

本校为通讯机构

院系归属：

化学化工学院

摘要：

Copper serves as a crucial trace element in various biological systems. Copper ions form complexes with different ligands, amplifying reactive oxygen species (ROS) levels and promoting intracellular ROS accumulation in multiple cancer cell types. In this study, a copper(II) complex, dichlorido[4-(5-bromothiazol-2-yl)-2,2'-bipyridine] copper(II) (Cu1), was synthesized using a terpyridine derivative as the ligand. Its structural configuration was confirmed through mass spectrometry and single-crystal X-ray diffraction analysis. The in vitro anticancer efficacy and mechanisms of Cu1 against B16-F...

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A copper complex with a thiazole-modified tridentate ligand: synthesis, structural characterization, and anticancer activity in B16-F10 melanoma cells

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