Hypoxic Upregulation of IER2 Increases Paracrine GMFG Signaling of Endoplasmic Reticulum Stress-CAF to Promote Chordoma Progression via Targeting ITGB1

首页 > 成果 > 详情

认领

导出

Link by DOI

反馈

作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Zhang, Tao-Lan;Zheng, Bo-Wen;Xia, Chao;Wu, Peng-Fei;Zheng, Bo-Yv;...

通讯作者：

Zou, MX;Zhou, H;Huang, W

作者机构：

[Zhang, Tao-Lan; Zheng, Bo-Wen] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Pharm, Hengyang 421001, Peoples R China.

[Zheng, Bo-Wen] Peking Univ, Peking Univ Peoples Hosp, Musculoskeletal Tumor Ctr, Beijing 100044, Peoples R China.

[Xia, Chao; Zou, MX; Zou, Ming-Xiang] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Spine Surg, Hengyang 421001, Peoples R China.

[Wu, Peng-Fei] Guangzhou Med Univ, Natl Childrens Med Ctr South Cent Reg, Guangzhou Women & Childrens Med Ctr, Dept Genet & Endocrinol, Guangzhou 510623, Guangdong, Peoples R China.

[Zheng, Bo-Yv] Gen Hosp Cent Theater Command, Dept Orthoped Surg, Wuhan 430061, Peoples R China.

通讯机构：

[Huang, W ; Zou, MX ; Zhou, H ] U

Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Spine Surg, Hengyang 421001, Peoples R China.

Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Radiol, Hengyang 421001, Peoples R China.

Univ South China, Affiliated Hosp 1, Hlth Management Ctr, Hengyang Med Sch, Hengyang 421001, Peoples R China.

语种：

英文

关键词：

cancer-associated fibroblasts;chordoma progression;endoplasmic reticulum stress;hypoxia;IER2/GMFG/ITGB1 axis;paracrine

期刊：

Advanced Science

ISSN：

2198-3844

年：

2024

卷：

期：

页码：

e2405421

DOI：

10.1002/advs.202405421

基金类别：

National Natural Science Foundation of China; Alpha X Biotech Co., Ltd.; China Scholarship Council [202106370071]; Natural Science Foundation of Hunan Province [2019JJ50542, 2023JJ50156, 2023JJ40596, 2023JJ40587, 2021JJ40509]; Hunan Provincial Natural Science Foundation for Excellent Youth Scholars [2023JJ20035]; Science and Technology Innovation Program of Hunan Province [2023RC3172]; University of South China [20224310NHYCG04, 20224310NHYCG03]; Project for Clinical Research of Hunan Provincial Health Commission [20201978, 20201962, 20201956]; Research Foundation of Education Bureau of Hunan Province [22B0441]

机构署名：

本校为第一且通讯机构

院系归属：

药学与生物科学学院

摘要：

Currently, the oncogenic mechanism of endoplasmic reticulum stress-CAF (ERS-CAF) subpopulation in chordoma remains unknown. Here, single-cell RNA sequencing, spatial transcriptomics, GeoMx Digital Spatial Profiler, data-independent acquisition proteomics, bulk RNA-seq, and multiplexed quantitative immunofluorescence are used to unveil the precise molecular mechanism of how ERS-CAF affected chordoma progression. Results show that hypoxic microenvironment reprograms CAFs into ERS-CAF subtype. Mechanistically, this occurrs via hypoxia-mediated transcriptional upregulation of IER2. Overexpression ...

反馈

产权有误：本人成果被他人认领

数据有误：数据基本信息有误

归属有误：成果的院系归属、机构署名归属有误

其他原因：

验证码：

看不清楚，换一个

确定

取消

成果认领

标题：

用户	作者	通讯作者	--
	请选择	请选择	--

确定

取消

Hypoxic Upregulation of IER2 Increases Paracrine GMFG Signaling of Endoplasmic Reticulum Stress-CAF to Promote Chordoma Progression via Targeting ITGB1

反馈

成果认领

提示

该栏目需要登录且有访问权限才可以访问