Endothelial-to-mesenchymal transition: A novel therapeutic target for cardiovascular diseases

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Jackson, Ampadu O.;Zhang, Jingjing;Jiang, Zhisheng;Yin, Kai*

通讯作者：

Yin, Kai

作者机构：

[Jackson, Ampadu O.] Univ South China, Int Coll, Hengyang, Hunan, Peoples R China.

[Yin, Kai; Jiang, Zhisheng; Jackson, Ampadu O.] Univ South China, Med Sch, Hengyang, Hunan, Peoples R China.

[Yin, Kai; Jiang, Zhisheng] Univ South China, Inst Cardiovasc Dis, Key Lab Atherosclerol Hunan Prov, Hengyang, Hunan, Peoples R China.

[Zhang, Jingjing] Univ South China, Affiliated Hosp 1, Dept Cardiol, Hengyang, Hunan, Peoples R China.

[Yin, Kai] Univ South China, Inst Cardiovasc Dis Res, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Yin, Kai] U

Univ South China, Inst Cardiovasc Dis Res, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

*Atherosclerosis;*Cardiovascular diseases;*EndMT;*Fibrotic disorders

期刊：

Trends in Cardiovascular Medicine

ISSN：

1050-1738

年：

2017

卷：

期：

页码：

383-393

DOI：

10.1016/j.tcm.2017.03.003

基金类别：

National Natural Sciences Foundation of China, ChinaNational Natural Science Foundation of China (NSFC) [81100213, 81470569]; Scientific Research Foundation for Doctor in University of South China, China [2015XQD49]; Scientific Research Foundation for the Returned Overseas Chinese Scholars in University of South ChinaScientific Research Foundation for the Returned Overseas Chinese Scholars [2015XQD55]; Construct Program of the Key Discipline in Hunan Province, China (Basic Medicine Sciences in University of South China, Xiangjiaofa) [[2011]76]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Endothelial-to-mesenchymal transition (EndMT) is a complex biological process in which endothelial cells lose their specific markers and acquire a mesenchymal or myofibroblastic phenotype. Similar to epithelial-to-mesenchymal transition (EMT), EndMT can be induced by multiple stimulants such as cytokines and metabolic factors that play crucial roles in the development of the cardiovascular system. Recent studies have demonstrated that EndMT may play a significant role in the pathogenesis of cardiovascular diseases (CVDs), and may represent a novel therapeutic target for cardiovascular remodeli...

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Endothelial-to-mesenchymal transition: A novel therapeutic target for cardiovascular diseases

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