期刊论文

Wei, Dangheng;Wang, Yu

英文

DNA AND CELL BIOLOGY

1044-5498

2017

36

11

883-891

10.1089/dna.2017.3779

This work was supported by the grants from the National Natural Science Foundation of China (31670962, 81370378), the Research project of graduate students in Hunan Province, China, 2017 (CX2017B551), and the Construct Program of the Key Discipline in Hunan Province.

本校为第一且通讯机构

Endothelial-to-mesenchymal transition (EndMT) is a cellular reprogramming mechanism by which endothelial cells acquire a mesenchymal phenotype. EndMT is associated with fibroproliferative diseases, such as cancer progression and metastasis and cardiac and kidney fibrosis, and this condition has been extensively investigated over the past decade. Recently, studies showed that EndMT contributes to the initiation and progression of atherosclerotic lesion and plaque destabilization. Unstable atherosclerotic plaque rupture and subsequent thrombosis are the main pathological causes of acute cardiova...