期刊论文

Xie, Feng;Chen, Linxi

英文

JOURNAL OF CELLULAR PHYSIOLOGY

0021-9541

2019

234

7

10032-10046

10.1002/jcp.27866

This study was supported by the grants from the National Natural Science Foundation of China (Grant No. 81503074), the Construct Program of the Key Discipline in Hunan Province, and Hunan Province Cooperative innovation Center for Molecular Target New Drug Study (Hunan Provincial Education Department Document; 2014‐405). This study was supported by the grants from the National Natural Science Foundation of China (Grant No. 81503074), the Construct Program of the Key Discipline in Hunan Province, and Hunan Province Cooperative innovation Center for Molecular Target New Drug Study (Hunan Provincial Education Department Document; 2014-405).

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Mitochondria play a key role in the maintenance of neuronal function by continuously providing energy. Here, we will give a detailed review about the recent developments in regards to dynamin-related protein 1 (Drp1) induced unbalanced mitochondrial dynamics, excessive mitochondrial division, and neuronal injury in neural system dysfunctions and neurodegenerative diseases, including the Drp1 knockout induced mice embryonic death, the dysfunction of the Drp1-dependent mitochondrial division induced neuronal cell apoptosis and impaired neuronal a...