F10 gene hypomethylation, a putative biomarker for glioma prognosis

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成果类型：

期刊论文

作者：

Liu, Xiaoping;Tang, Hailin;Wang, Zeyou;Huang, Chen;Zhang, Zuping;...

通讯作者：

Wu, Minghua

作者机构：

[Wu, Minghua; She, Xiaoling; Tang, Hailin; Wang, Zeyou; Zhang, Zuping; Li, Guiyuan; Liu, Xiaoping] Cent S Univ, Canc Res Inst, Changsha, Hunan, Peoples R China.

[Wu, Minghua; She, Xiaoling; Tang, Hailin; Wang, Zeyou; Zhang, Zuping; Li, Guiyuan; Liu, Xiaoping] Cent S Univ, Dis Genome Res Ctr, Changsha, Hunan, Peoples R China.

[Wu, Minghua; She, Xiaoling; Tang, Hailin; Wang, Zeyou; Zhang, Zuping; Li, Guiyuan; Liu, Xiaoping] Minist Educ, Key Lab Carcinogenesis & Canc Invas, Changsha, Hunan, Peoples R China.

[Wu, Minghua; She, Xiaoling; Tang, Hailin; Wang, Zeyou; Zhang, Zuping; Li, Guiyuan; Liu, Xiaoping] Minist Hlth, Key Lab Carcinogenesis, Changsha, Hunan, Peoples R China.

[Tang, Hailin] Univ S China, Canc Res Inst, Hengyang 421001, Peoples R China.

通讯机构：

[Wu, Minghua] C

Cent S Univ, Canc Res Inst, 110 Xiangya Rd, Changsha, Hunan, Peoples R China.

语种：

英文

关键词：

Glioma;F10;Hypomethylation;Prognosis

期刊：

Journal of Neuro-Oncology

ISSN：

0167-594X

年：

2012

卷：

107

期：

页码：

479-485

DOI：

10.1007/s11060-011-0775-2

基金类别：

111 projectMinistry of Education, China - 111 Project [111-2-12]; National Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81171932, 30901539, 30901718]; Program for New Century Excellent Talents in UniversityProgram for New Century Excellent Talents in University (NCET) [NCET-08-0562]; Hunan Province Natural Sciences Foundations of ChinaNatural Science Foundation of Hunan Province [11JJ1013]

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

Tumors are usually characterized by an imbalance in cytosine methylation, including hypomethylation of CpG islands. In this study, bisulfite sequencing PCR was used to assess the promoter methylation status of coagulation factor X (F10) gene in tumors of 96 glioma patients and in glioma cells U251, SF767, and SF126, and the effect of promoter hypomethylation on protein expression was evaluated immunohistochemically. The study showed that the demethylation ratio of F10 in SF126, SF767, and U251 cells was 38.6, 26.4, and 24.3% respectively. Hypomethylation of F10 was detected in 82.3% of glioma ...

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F10 gene hypomethylation, a putative biomarker for glioma prognosis

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