期刊论文

中文

实用癌症杂志

1001-5930

1999

14

3

180-181

国家自然科学基金

本校为第一机构

采用免疫组化和逆转录ＰＣＲ技术，分别检测甲状腺癌ｂｃｌ－２蛋白及ｂｃｌ－２ｍＲＮＡ的表达，结果显示，２０例甲状腺癌中ｂｃｌ－２蛋白阳性１４例；８例良性甲状腺肿瘤及８例Ｇｒａｖｅｓ病均阴性，１２例甲状腺癌新鲜手术标本中８例ｂｃｌ－２ｍＲＮＡ表达阳性，而其癌旁组织ｂｃｌ－２ｍＲＮＡ表达阴性，结果表明，ｂｃｌ－２蛋白及ｂｃｌ－２ｍＲＮＡ异常表达与甲状腺细胞凋亡减少有关，在甲状腺癌发生中起一定作用。

Using immunohistochemical staining method and reverse transcription polymerase chain reaction(RT PCR),we analyzed the expression of bcl 2 protein and bcl 2 mRNA in thyroid carcinomas.The results showed that the expression of bcl 2 protein in 14 thyroid carcinomas were positive,and in 8 benign thyroid tumors and 8 Graves′ disease it was negative.The expression of bcl 2 mRNA was positive in 8 thyroid carcinomas.It suggests that excessive expression of bcl 2 protein and bcl 2 mRNA are involv...