Dynamic Schiff base linkage-based double-network hydrogels with injectable, self-healing, and pH-responsive properties for bacteria-infected wound healing

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Du, Wenfang;Li, Hong;Luo, Jie;Wang, Yuxiao;Xi, Qiang;...

通讯作者：

Xiao, FB;Li, Junjie

作者机构：

[Liu, Jie; Yang, Shengyuan; Du, Wenfang; Xiao, Fubing; Li, Hong; Wang, Yuxiao; Luo, Jie] Univ South China, Sch Publ Hlth, Hengyang Med Sch, Hunan Key Lab Typ Environm Pollut & Hlth Hazards, Hengyang 421001, Peoples R China.

[Du, Wenfang; Li, Junjie; Xiao, Fubing; Xi, Qiang; Li, JJ] Hunan Univ, Coll Chem & Chem Engn, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Peoples R China.

[Du, Wenfang] Binzhou Univ, Coll Biol & Environm Engn, Binzhou 256600, Peoples R China.

[Xi, Qiang] Univ South China, Hunan Prevent & Treatment Inst Occupat Dis, Affiliated Prevent & Treatment Inst Occupat Dis, Changsha 410007, Peoples R China.

通讯机构：

[Xiao, FB ] U

[Li, JJ] H

Univ South China, Sch Publ Hlth, Hengyang Med Sch, Hunan Key Lab Typ Environm Pollut & Hlth Hazards, Hengyang 421001, Peoples R China.

Hunan Univ, Coll Chem & Chem Engn, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Peoples R China.

语种：

英文

关键词：

Dialdehyde carboxymethyl cellulose;Double-network hydrogel;Self-healing;On-demand drug release;Infected wound healing

期刊：

Cellulose

ISSN：

0969-0239

年：

2024

卷：

期：

页码：

6373-6385

DOI：

10.1007/s10570-024-05972-z

基金类别：

This work was supported by the National Natural Science Foundation of China (21906077, 82073604), the Natural Science Foundation of Hunan Province (2020JJ5474), the Scientific Research Foundation of Hunan Provincial Education Department (23A0346), the Postdoctoral Science Foundation of China (2021M701161, 2021M690053), the Natural Science Foundation of Shandong Province (ZR2020QB095), and the Changsha Municipal Natural Science Foundation (kq2202144).

机构署名：

本校为第一且通讯机构

院系归属：

公共卫生学院

摘要：

The development of wound dressing materials with both self-healing and antibacterial properties for promoting wound closure is highly desirable in health care. Herein, a smart double-network hydrogel (GS/DPPDH) with promising traits was developed by combining a dynamic Schiff base reaction between dialdehyde carboxymethyl cellulose (DCMC) and poly(ethylene imine) (PEI) with free radical polymerization. Because of its abundant amino groups, the common antibacterial drug gentamycin sulfate (GS) can be loaded into hydrogels by the formation of Schiff base bonds with DCMC. The slightly acidic woun...

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Dynamic Schiff base linkage-based double-network hydrogels with injectable, self-healing, and pH-responsive properties for bacteria-infected wound healing

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