Synthesis and anti-thyroid cancer effect of iodo-chrysin derivatives

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成果类型：

期刊论文

作者：

Wei, Yun;Zheng, Qutong;Tang, Guotao;Song, Chen;Wang, Guan;...

通讯作者：

Zheng, Xing

作者机构：

[Song, Chen; Xiao, Yan; Wang, Zongbao; Wang, Guan; Zheng, Qutong; Wei, Yun; Tang, Guotao; Zhang, Yinxiang; Zeng, Xianliang; Zheng, Xing] Univ South China, Inst Pharm & Pharmacol, Hengyang 421001, Peoples R China.

[Song, Chen; Xiao, Yan; Wang, Zongbao; Wang, Guan; Zheng, Qutong; Wei, Yun; Tang, Guotao; Zhang, Yinxiang; Zeng, Xianliang; Xiao, Jichang; Zheng, Xing] Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Peoples R China.

[Song, Chen; Wang, Guan; Zhang, Yinxiang] Univ South China, Res Interest Grp Pharm, Hengyang 421001, Peoples R China.

[Xiao, Jichang] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, Shanghai 200032, Peoples R China.

通讯机构：

[Zheng, Xing] U

Univ South China, Inst Pharm & Pharmacol, Hengyang 421001, Peoples R China.

语种：

英文

关键词：

Anti-thyroid cancer;activities;Baker-Venkataraman reaction;flavonoids;iodo-chrysin derivatives;MTT method.

期刊：

MEDICINAL CHEMISTRY

ISSN：

1573-4064

年：

2016

卷：

期：

页码：

441-447

DOI：

10.2174/1573406411666150921111220

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81273537]; Scientific Research Fund of Hunan Provincial Education DepartmentHunan Provincial Education Department [12K095]; key disciplines of Hunan Province

机构署名：

本校为第一且通讯机构

院系归属：

药学与生物科学学院

摘要：

A novel series of iodo-chrysin derivatives with resorcinol as raw materials were synthesized according to Baker-Venkataraman reaction and their inhibitory activities in vitro against thyroid cancer cell lines (SW-579 and TT) were evaluated by the standard methyl thiazole tetrazolium (MTT) method. Biological test results showed that these derivatives possessed stronger anti-thyroid cancer activities than 5-FU. Compound 21 showed the strongest activity against SW-579 cell lines with IC50 value of 3.4μM and compound 10 showed the strongest activi...

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Synthesis and anti-thyroid cancer effect of iodo-chrysin derivatives

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