In Situ Activated NK Cell as Bio-Orthogonal Targeted Live-Cell Nanocarrier Augmented Solid Tumor Immunotherapy

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成果类型：

期刊论文

作者：

Meng, Dandan;Pan, Hong;He, Wei;Jiang, Xing;Liang, Zhenguo;...

通讯作者：

Gong, Ping;Li, Wenjun;Cai, LT

作者机构：

[Li, Wenjun; Zhang, Xu; Li, WJ; Meng, Dandan; Cai, Lintao; Xu, Xiaoyu; Gong, Ping; Pan, Hong; Liang, Zhenguo; Jiang, Xing; Gong, P; He, Wei; Wang, Zixi; Zheng, Jinling] Chinese Acad Sci, Shenzhen Inst Adv Technol SIAT, CAS HK Joint Lab Biomat Shenzhen Engn Lab Nanomed, Guangdong Key Lab Nanomed, Shenzhen 518055, Peoples R China.

[Meng, Dandan; Zheng, Jinling] Univ South China, Sch Pharmaceut Sci, China Hunan Prov Key Lab Tumor Microenvironm Resp, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Peoples R China.

[Li, Wenjun; Zhang, Xu; Li, WJ; Cai, Lintao; Gong, Ping; Pan, Hong; Liang, Zhenguo; Gong, P; Wang, Zixi] Univ Chinese Acad Sci, Beijing 100049, Peoples R China.

通讯机构：

[Li, WJ; Gong, P; Cai, LT ] C

Chinese Acad Sci, Shenzhen Inst Adv Technol SIAT, CAS HK Joint Lab Biomat Shenzhen Engn Lab Nanomed, Guangdong Key Lab Nanomed, Shenzhen 518055, Peoples R China.

Univ Chinese Acad Sci, Beijing 100049, Peoples R China.

语种：

英文

关键词：

bio-orthogonal targeting;cellular immunotherapy;immune activation;immune regulation;live-cell nanocarriers;precision delivery

期刊：

Advanced Functional Materials

ISSN：

1616-301X

年：

2022

卷：

期：

页码：

2202603

DOI：

10.1002/adfm.202202603

基金类别：

Guangdong Provincial Key Area R&D Program, (2020B1111540001) Shenzhen-Macao Technology Plan Shenzhen‐Macao Technology Plan, (SGDX2020110309280301) National Natural Science Foundation of China, NSFC, (81971749) National Natural Science Foundation of China, NSFC Natural Science Foundation of Guangdong Province, (2021A1515010195, 2022A1515010780) Natural Science Foundation of Guangdong Province Science, Technology and Innovation Commission of Shenzhen Municipality, (GJHZ20200731095206020, JCYJ20200109114616534, JCYJ20210324101403009, JCYJ20210324101807020, JCYJ20210324115804013) Science, Technology and Innovation Commission of Shenzhen Municipality National Key Research and Development Program of China, NKRDPC, (2021YFA0910001) National Key Research and Development Program of China, NKRDPC

机构署名：

本校为其他机构

院系归属：

药学与生物科学学院

摘要：

Natural killer (NK) cell-based immunotherapy holds prominent potential for cancer treatment. However, its application in solid tumors is limited by a rapid decline in viability and function, as well as inadequate homing and infiltration. Herein, a generalized strategy is offered to construct a bio-orthogonal targeted live-cell nanocarrier (N3-NK-NPs) by coupling with responsive released interleukin-21 (IL-21) nanoparticles (ILNPs) on glyco-engineered NK cell surfaces. Complementary bio-orthogonal groups (azide (N3)/bicyclo [6.1.0] nonyne (BCN),...

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In Situ Activated NK Cell as Bio-Orthogonal Targeted Live-Cell Nanocarrier Augmented Solid Tumor Immunotherapy

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