In Situ Activated NK Cell as Bio-Orthogonal Targeted Live-Cell Nanocarrier Augmented Solid Tumor Immunotherapy

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成果类型：

期刊论文

作者：

Meng, Dandan;Pan, Hong;He, Wei;Jiang, Xing;Liang, Zhenguo;...

通讯作者：

Gong, Ping;Li, Wenjun;Cai, LT

作者机构：

[Li, Wenjun; Zhang, Xu; Li, WJ; Meng, Dandan; Cai, Lintao; Xu, Xiaoyu; Gong, Ping; Pan, Hong; Liang, Zhenguo; Jiang, Xing; Gong, P; He, Wei; Wang, Zixi; Zheng, Jinling] Chinese Acad Sci, Shenzhen Inst Adv Technol SIAT, CAS HK Joint Lab Biomat Shenzhen Engn Lab Nanomed, Guangdong Key Lab Nanomed, Shenzhen 518055, Peoples R China.

[Meng, Dandan; Zheng, Jinling] Univ South China, Sch Pharmaceut Sci, China Hunan Prov Key Lab Tumor Microenvironm Resp, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Peoples R China.

[Li, Wenjun; Zhang, Xu; Li, WJ; Cai, Lintao; Gong, Ping; Pan, Hong; Liang, Zhenguo; Gong, P; Wang, Zixi] Univ Chinese Acad Sci, Beijing 100049, Peoples R China.

通讯机构：

[Li, WJ; Gong, P; Cai, LT ] C

Chinese Acad Sci, Shenzhen Inst Adv Technol SIAT, CAS HK Joint Lab Biomat Shenzhen Engn Lab Nanomed, Guangdong Key Lab Nanomed, Shenzhen 518055, Peoples R China.

Univ Chinese Acad Sci, Beijing 100049, Peoples R China.

语种：

英文

关键词：

bio-orthogonal targeting;cellular immunotherapy;immune activation;immune regulation;live-cell nanocarriers;precision delivery

期刊：

Advanced Functional Materials

ISSN：

1616-301X

年：

2022

卷：

期：

页码：

2202603-

DOI：

10.1002/adfm.202202603

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81971749]; Guangdong Provincial Key Area RD Program [2020B1111540001]; Natural Science Foundation of Guangdong ProvinceNational Natural Science Foundation of Guangdong Province [2021A1515010195, 2022A1515010780]; Shenzhen Science and Technology Program [GJHZ20200731095206020, JCYJ20210324101403009, JCYJ20200109114616534, JCYJ20210324101807020, JCYJ20210324115804013]; Shenzhen-Macao Technology Plan [SGDX2020110309280301]; National Key Research and Development Program of China [2021YFA0910001]

机构署名：

本校为其他机构

院系归属：

药学与生物科学学院

摘要：

AbstractNatural killer (NK) cell‐based immunotherapy holds prominent potential for cancer treatment. However, its application in solid tumors is limited by a rapid decline in viability and function, as well as inadequate homing and infiltration. Herein, a generalized strategy is offered to construct a bio‐orthogonal targeted live‐cell nanocarrier (N3‐NK‐NPs) by coupling with responsive released interleukin‐21 (IL‐21) nanoparticles (ILNPs) on glyco‐engineered NK cell surfaces. Complementary bio‐orthogonal groups (azide (N3)/bicyclo [6.1...

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In Situ Activated NK Cell as Bio-Orthogonal Targeted Live-Cell Nanocarrier Augmented Solid Tumor Immunotherapy

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