Urolithin a Improves Motor Dysfunction Induced by Copper Exposure in SOD1G93A Transgenic Mice Via Activation of Mitophagy - 成果

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Urolithin a Improves Motor Dysfunction Induced by Copper Exposure in SOD1^G93A Transgenic Mice Via Activation of Mitophagy

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成果类型：

期刊论文

作者：

Zhang, Huan;Gao, Chuanyue;Yang, Deguang;Nie, Lulin;He, Kaiwu;...

通讯作者：

Yang, XF;Zou, LY;Zhang, ZH

作者机构：

[Huang, Guanqin; Liu, Jianjun; Zhou, Li; Yang, Xifei; Wu, Desheng; Huang, Xinfeng; Gao, Chuanyue; Li, Shangming; Nie, Lulin; He, Kaiwu; Zhang, Huan; Yang, XF; Chen, Chongyang] Shenzhen Ctr Dis Control & Prevent, Shenzhen Key Lab Modern Toxicol, Shenzhen Med Key Discipline Hlth Toxicol 2020 2024, Shenzhen 518055, Peoples R China.

[Gao, Chuanyue] Xian Int Med Ctr Hosp, Xian 710100, Peoples R China.

[Yang, Deguang] Jinan Univ, Affiliated Hosp 5, Heyuan Shenhe Peoples Hosp, Dept Cardiol, Heyuan 517000, Peoples R China.

[Nie, Lulin] Jinan Univ, Coll Pharm, Guangzhou 510632, Peoples R China.

[Huang, Zhenlie] Southern Med Univ, Sch Publ Hlth, NMPA Key Lab Safety Evaluat Cosmet, Guangdong Prov Key Lab Trop Dis Res,Dept Toxicol, Guangzhou 510515, Peoples R China.

通讯机构：

[Yang, XF ; Zou, LY ] S

[Zhang, ZH ] U

Shenzhen Ctr Dis Control & Prevent, Shenzhen Key Lab Modern Toxicol, Shenzhen Med Key Discipline Hlth Toxicol 2020 2024, Shenzhen 518055, Peoples R China.

Southern Univ Sci & Technol, Jinan Univ, Affiliated Hosp 1, Shenzhen Peoples Hosp,Clin Med Coll 2,Dept Neurol, Shenzhen, Peoples R China.

Univ South China, Sch Publ Hlth, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

Amyotrophic lateral sclerosis;Copper;Mitophagy;Motor dysfunction;Urolithin A

期刊：

Molecular Neurobiology

ISSN：

0893-7648

年：

2024

页码：

1-16

DOI：

10.1007/s12035-024-04473-1

基金类别：

This study was supported in parts by grants from NSFC (82171583); The Key Basic Research Program of Shenzhen Science and Technology Innovation Commission (JCYJ20200109150717745; JCYJ20200109144418639); Shenzhen Key Medical Discipline Construction Fund (SZXK069), Sanming Project of Medicine in Shenzhen (SZSM201611090); Study on Photothermal tumor Vaccine, Shenzhen Science and Technology Innovation Commission (JCYJ20200109120205924).

机构署名：

本校为通讯机构

院系归属：

公共卫生学院

摘要：

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease pathologically characterized by selective degeneration of motor neurons resulting in a catastrophic loss of motor function. The present study aimed to investigate the effect of copper (Cu) exposure on progression of ALS and explore the therapeutic effect and mechanism of Urolithin A (UA) on ALS. 0.13 PPM copper chloride drinking water was administrated in SOD1(G93A) transgenic mice at 6weeks, UA at a dosage of 50mg/kg/day was given for 6weeks after a 7-week Cu exposure. Motor ability was assessed before terminal anesthesia. Mus...

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Urolithin a Improves Motor Dysfunction Induced by Copper Exposure in SOD1^G93A Transgenic Mice Via Activation of Mitophagy

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