Identifying DCN and HSPD1 as potential biomarkers in colon cancer using 2D-LC-MS/MS combined with iTRAQ technology

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Li, Guoqing;Li, Maoyu;Liang, Xujun;Xiao, Zhefeng;Zhang, Pengfei;...

通讯作者：

Li, Yuanyuan;Chen, Zhuchu

作者机构：

[Li, Maoyu; Li, YY; Chen, Zhuchu; Li, Yuanyuan; Peng, Fang; Xiao, Zhefeng; Zhang, Pengfei; Shao, Meiying; Chen, Yongheng; Li, Guoqing; Liang, Xujun] Cent S Univ, Xiangya Hosp, Chinese Minist Hlth, Key Lab Canc Prote, 87 Xiangya Rd, Changsha 410008, Hunan, Peoples R China.

[Li, Guoqing] Univ South China, Sch Pharm & Life Sci, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Hunan, Peoples R China.

[Li, Yuanyuan] Guangxi Univ Sci & Technol, Coll Med, Liuzhou 545005, Guangxi, Peoples R China.

通讯机构：

[Li, YY; Chen, ZC] C

[Li, Yuanyuan] G

Cent S Univ, Xiangya Hosp, Chinese Minist Hlth, Key Lab Canc Prote, 87 Xiangya Rd, Changsha 410008, Hunan, Peoples R China.

Guangxi Univ Sci & Technol, Coll Med, Liuzhou 545005, Guangxi, Peoples R China.

语种：

英文

关键词：

biological marker;chaperonin 60;decorin;Article;cancer diagnosis;colon cancer;controlled study;human;human tissue;immunohistochemistry;isobaric tags for relative and absolute quantitation;laser capture microdissection;liquid chromatography-mass spectrometry;protein expression;protein protein interaction;proteomics;quantitative analysis;signal transduction;Western blotting

期刊：

JOURNAL OF CANCER

ISSN：

1837-9664

年：

2017

卷：

期：

页码：

479-489

DOI：

10.7150/jca.17192

基金类别：

Grants were provided by the National Natural Science Foundation of China (No. 81272971, No. 81202129, and No. 81372516), the National Key Basic Research Program of China (973 Program) (No. 2011CB910704 and No. 2014CBA02004), the Project of Scientific Research Fund of Hunan Provincial Education Department (No. 16C1409), and the Natural Science Foundation of Hunan Province of China (No. 2016JJ5013).

机构署名：

本校为其他机构

院系归属：

药学与生物科学学院

摘要：

Colon cancer is one of the most common types of gastrointestinal cancers and the fourth cause of cancer death worldwide. To discover novel diagnostic biomarkers for colon cancer and investigate potential mechanisms of oncogenesis, quantitative proteomic approach using iTRAQ-tagging and 2D-LC-MS/MS was performed to characterize proteins alterations in colon cancer and non-neoplastic colonic mucosa (NNCM) using laser capture microdissection-harvested from the two types of tissues, respectively. As a result, 188 DEPs were identified, and the diffe...

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Identifying DCN and HSPD1 as potential biomarkers in colon cancer using 2D-LC-MS/MS combined with iTRAQ technology

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